Book ChapterDOI
Regulation of mammalian pyruvate dehydrogenase complex by a phosphorylation-dephosphorylation cycle.
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This article is published in Current Topics in Cellular Regulation.The article was published on 1981-01-01. It has received 148 citations till now. The article focuses on the topics: Pyruvate dehydrogenase complex & Pyruvate decarboxylation.read more
Citations
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Journal ArticleDOI
The pharmacology of dichloroacetate.
TL;DR: Despite its potential toxicity and limited clinical experience, DCA and its derivatives may prove to be useful in probing regulatory aspects of intermediary metabolism and in the acute or chronic treatment of several metabolic disorders.
Book ChapterDOI
The Central Metabolic Pathways of Escherichia coli: Relationship between Flux and Control at a Branch Point, Efficiency of Conversion to Biomass, and Excretion of Acetate
TL;DR: This chapter reviews the relationship between flux and control at a branch point, efficiency of conversion to biomass, and excretion of acetate, which focuses on the central metabolic pathways of Escherichia coli.
References
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Journal ArticleDOI
α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION
TL;DR: The discovery that the activity of the multienzyme pyruvate dehydrogenase complex from beef kidney mitochondria is regulated by a phosphorylation-dephosphorylation reaction sequence is reported.
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Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide.
TL;DR: This paper showed that pyruvate dehydrogenase in perfused rat heart was decreased by alloxan-diabetes or by perfusion with media containing acetate, n-octanoate or palmitate.
Journal ArticleDOI
Regulation of adipose-tissue pyruvate dehydrogenase by insulin and other hormones
TL;DR: It is concluded that insulin accelerates a step in the span pyruvate-->fatty acid as well as the control of fatty acid synthesis in adipose tissue and the role of cyclic AMP in mediating the effects of insulin on pyruVate dehydrogenase.
Journal ArticleDOI
α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA
TL;DR: The activity of the multienzyme pyruvate dehydrogenase complexes, isolated from mitochondria of beef kidney, beef heart, and pork liver, is regulated by phosphorylation and dephosphorylation.
Journal ArticleDOI
Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios.
TL;DR: The interconversion of the active, nonphosphorylation form of pyruvate dehydrogenase and its inactive, phosphorylated form is modulated by acetyl-CoA/CoA and NADH/NAD molar ratios.