Journal ArticleDOI
Retrograde ejaculation after anterior lumbar interbody fusion with and without bone morphogenetic protein-2 augmentation: a 10-year cohort controlled study.
Garet C. Comer,Micah W. Smith,Eric L. Hurwitz,Kyle A. Mitsunaga,Robert Kessler,Eugene J. Carragee +5 more
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This study confirms previous reports of a higher rate of RE in ALIF procedures using rhBMP-2 and an open anterior approach to the spine, and confirms the magnitude of the RE effect may be increased with concomitant prostatic disease treatments.About:
This article is published in The Spine Journal.The article was published on 2012-10-01. It has received 103 citations till now. The article focuses on the topics: Urinary retention & Retrospective cohort study.read more
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A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2
Aaron W. James,Gregory LaChaud,Jia Shen,Greg Asatrian,Vi Nguyen,Xinli Zhang,Kang Ting,Chia Soo +7 more
TL;DR: BMP-2 is a potent osteoinductive cytokine that has indeed revolutionized the bone graft substitute market; however, it simultaneously has accrued a worrisome side effect profile.
Journal ArticleDOI
Complications with the use of bone morphogenetic protein 2 (BMP-2) in spine surgery
Chadi Tannoury,Howard S. An +1 more
TL;DR: This article will provide the reader with a good understanding of the reported complications associated with rhBMP-2 use and ultimately help recognize its safety spectrum and limits for better clinical application.
Journal ArticleDOI
Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data.
Mark Simmonds,Jennifer Valeska Elli Brown,Morag Heirs,Julian P T Higgins,Richard Mannion,Mark Rodgers,Lesley A. Stewart +6 more
TL;DR: Recombinant human bone morphogenetic protein-2 increases fusion rates, reduces pain by a clinically insignificant amount, and increases early postsurgical pain compared with ICBG, and evidence of increased cancer incidence is inconclusive.
Journal Article
Safety and Effectiveness of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Fusion
Mark Simmonds,Jennifer Valeska Elli Brown,Morag Heirs,Julian P T Higgins,Richard Mannion,Mark Rodgers,Lesley A. Stewart +6 more
TL;DR: In this article, the authors found that rhBMP-2 increases fusion rates, reduces pain by a clinically insignificant amount, and increases early postsurgical pain compared with ICBG.
Journal ArticleDOI
Complications due to the use of BMP/INFUSE in spine surgery: The evidence continues to mount.
TL;DR: There is mounting evidence in the spinal literature that utilizing BMP/INFUSE in spinal fusions contributes to major perioperative and postoperative morbidity.
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Williams Textbook of Endocrinology
TL;DR: Williams textbook of endocrinology / , Williams textbooks of endocrineology /, کتابخانه دیجیتال جندی اهواز
Journal ArticleDOI
Better reporting of harms in randomized trials: an extension of the CONSORT statement.
John P. A. Ioannidis,Stephen J. W. Evans,Peter C Gøtzsche,Robert T O'Neill,Douglas G. Altman,Kenneth F. Schulz,David Moher +6 more
TL;DR: This work searched MEDLINE, EMBASE, Web of Science, and the Cochrane Library using a wide array of terms related to harms and identified pertinent evidence and made recommendations on the appropriate reporting of harms in RCTs.
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A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned
TL;DR: An estimate of adverse events associated with rhBMP-2 use in spine fusion is suggested ranging from 10 to 50 times the original estimates reported in the industry-sponsored peer-reviewed publications, as well as a clear increased risk of complications and adverse events to patients receiving rhB MP-2 in spinal fusion.
Journal ArticleDOI
Anterior Lumbar Interbody Fusion Using rhBMP-2 With Tapered Interbody Cages
TL;DR: Lumbar fusion using rhBMP-2 and a tapered titanium fusion cage can yield a solid union and eliminate the need for harvesting iliac crest bone graft in patients with degenerative lumbar disc disease.
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Safety profile for the clinical use of bone morphogenetic proteins in the spine.
Ashley R. Poynton,Joseph M. Lane +1 more
TL;DR: Findings show that RhBMP-2 has an antiproliferative effect on many cancer cells, and no evidence exists that it is carcinogenic, and it is unlikely that OP-1 has carcinogenic potential.