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Review of biological activity of withanolides

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This article is published in Journal of Scientific & Industrial Research.The article was published on 1987-01-01 and is currently open access. It has received 76 citations till now.

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Studies on the immunomodulatory effects of Ashwagandha.

TL;DR: Treatment with Ashwagandha was accompanied by significant increases in hemolytic antibody responses towards human erythrocytes, which prevented myelosuppression in mice treated with all three immunosuppressive drugs tested.
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An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda.

TL;DR: Withania somnifera (WS) is an anti-inflammatory and anti-arthritic agent and was found useful in clinical cases of Rheumatoid and Osteoarthritis and neurodegenerative diseases such as Parkinson's, Huntington's and Alzeimer's diseases.
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Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study.

TL;DR: The clinical efficacy of a herbomineral formulation containing roots of Withania somnifera, the stem of Boswellia serrata, rhizomes of Curcuma longa and a zinc complex, was evaluated in patients with osteoarthritis.
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Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation.

TL;DR: The immunomodulatory activities of an Indian Ayurvedic medicinal preparation, i.e. WST and WS2, were studied in mice for immune inflammation: active paw anaphylaxis and delayed type hypersensitivity (DTH), revealing a significant increase in white blood cell counts and platelet counts.
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Antistressor effect of Withania somnifera.

TL;DR: Withania somnifera is an Indian medicinal plant used widely in the treatment of many clinical conditions in India and its antistressor properties have been investigated using adult Wistar strain albino rats and cold water swimming stress test.
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