Journal ArticleDOI
Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation.
TLDR
The immunomodulatory activities of an Indian Ayurvedic medicinal preparation, i.e. WST and WS2, were studied in mice for immune inflammation: active paw anaphylaxis and delayed type hypersensitivity (DTH), revealing a significant increase in white blood cell counts and platelet counts.About:
This article is published in Journal of Ethnopharmacology.The article was published on 1999-10-01. It has received 235 citations till now. The article focuses on the topics: Withania somnifera & Delayed hypersensitivity.read more
Citations
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Cancer—an ayurvedic perspective
TL;DR: Review of literature on anticancer drugs of plant origin revealed identification of newer ayurvedic drugs that are not mentioned in the ancient texts, and details of experimental and clinical studies conducted on single and compound ayuvedic preparations for their anticancer efficacy strongly emphasize ayur Vedic therapy as a scientifically driven one and not simply unconventional.
Journal ArticleDOI
Ethnopharmacology and drug discovery.
TL;DR: The ethnopharmacology knowledge, its holistic and systems approach supported by experiential base can serve as an innovative and powerful discovery engine for newer, safer and affordable medicines.
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Withaferin A Causes FOXO3a- and Bim-Dependent Apoptosis and Inhibits Growth of Human Breast Cancer Cells In vivo
TL;DR: The WA treatment decreased viability of MCF-7 and MDA-MB-231 human breast cancer cells in a concentration-dependent manner and pointed toward an important role of FOXO3a and Bim in regulation of WA-mediated apoptosis in human breast cancers.
Journal ArticleDOI
The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from indian winter cherry
TL;DR: Results demonstrate that the tumor proteasome β5 subunit is the primary target of Withaferin A, and inhibition of the proteasomal chymotrypsin-like activity by WA in vivo is responsible for, or contributes to, the antitumor effect of this ancient medicinal compound.
Journal ArticleDOI
Pharmacologic overview of Withania somnifera, the Indian Ginseng
TL;DR: Withania somnifera is a potential drug candidate to treat various clinical conditions, particularly related to the nervous system, and the mechanisms of action and potential therapeutic applications of the plant and its active constituents are discussed.
References
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New substances of plant origin which increase nonspecific resistance
I I Brekhman,I V Dardymov +1 more
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Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses.
TL;DR: The results suggest that antibody feedback is not the sole regulator of delayed reactions; the possibility that suppressor T cells may also be involved is discussed.
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Studies on the immunomodulatory effects of Ashwagandha.
TL;DR: Treatment with Ashwagandha was accompanied by significant increases in hemolytic antibody responses towards human erythrocytes, which prevented myelosuppression in mice treated with all three immunosuppressive drugs tested.
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Enhancement of delayed hypersensitivity by depletion of suppressor T cells with cyclophosphamide in mice.
TL;DR: Treatment of mice with cyclophosphamide significantly affects delayed hypersensitivity reaction to methylated human serum albumin (MHSA) which induces little antibody production, and it is reported that the enhanced DH reaction is caused by damage to T rather than B cells.
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A comparative pharmacological investigation of Ashwagandha and Ginseng.
TL;DR: The aqueous suspensions of roots of an Indian drug Ashwagandha and the Korean drug Ginseng were tested comparatively for 2 pharmacological activities, namely the anti-stress activity by the 'mice swimming endurance test' and anabolic activity by noting gain in body weights and levator ani muscle in rats.