Open AccessJournal Article
Risk Factors and Phenytoin Prophylaxis for Early Post-Traumatic Seizures among Patients with Traumatic Brain Injury.
TLDR
The study showed that antiepileptic drug was not beneficial in preventing late post-traumatic seizures, but may have a role in preventing early seizures, and younger as well as intubated patients were at a higher risk of developing this condition.Abstract:
Background: Post-traumatic seizure is a well-known and serious
complication of traumatic brain injury (TBI). The incidence and risk
factors vary among study populations. Very little data have been
published concerning this in the Malaysian population. The aim of this
study was to ascertain the risk factors for the development of early
post-traumatic seizures among patients with TBI. Methods: This was a
prospective observational study, carried out in Hospital Universiti
Sains Malaysia, Kubang Kerian, Kelantan, under the Department of
Neurosciences. A total of 157 patients, from all age groups, who were
diagnosed with TBI were enrolled from June 2007 to December 2007. They
were followed-up for 12 months until death or their first
post-traumatic seizure. Survival analysis with Kaplan–Meier
curves and Cox proportional hazards regression was performed. Results:
A total of 11 (7.0%) of the patients developed early post-traumatic
seizures. The risk factors for early post-traumatic seizures were young
age (P = 0.021, 95% CI 0.806 to 0.982) and intubated patients (P =
0.029, 95% CI 1.194 to 25.913). The incidence of early post-traumatic
seizures in the local population was 7.0%. Conclusion: The incidence of
early post-traumatic seizures in the local population of Kelantan and
Terengganu is comparable to the incidences reported elsewhere. Younger
as well as intubated patients were at a higher risk of developing this
condition. It may be necessary to give antiepileptic prophylaxis
because any seizure could adversely affect morbidity and mortality.
However, the study showed that antiepileptic drug was not beneficial in
preventing late post-traumatic seizures, but may have a role in
preventing early seizures.read more
Citations
More filters
Journal ArticleDOI
Impact of late post-traumatic seizures on physical health and functioning for individuals with brain injury within the community.
Stephanie A. Kolakowsky-Hayner,Jerry Wright,Jeffrey Englander,Thao Duong,Susan E. Ladley-O’Brien +4 more
TL;DR: Individuals with TBI and LPTS are at a double-barrelled disadvantage regarding ongoing physical, cognitive, psychosocial and reintegration issues following brain injury and epilepsy.
Journal ArticleDOI
Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats
TL;DR: Assessment of the profile of a novel anticonvulsant, lacosamide (Vimpat) on post-TBI structural, motor and cognitive outcomes and injuries found that acute treatment with LCM had no protective effects on post/after traumatic brain injury structural or functional impairment.
Journal Article
Comparison Of Efficacy Of Phenytoin And Levetiracetam For Prevention Of Early Post Traumatic Seizures.
Shahbaz Ali Khan,Sajid Nazir Bhatti,Aftab Alam,Ehtisham Ahmed Khan Afridi,Gul Muhammad,Khalid Khan Zadran,Sudhair Alam,Ahsan Aurangzeb +7 more
TL;DR: There is no statistically significant difference in the efficacy of Phenytoin and Levetiracetam in prophylaxis of early posttraumatic seizures in cases of moderate to severe traumatic brain injury.
Journal ArticleDOI
Epilepsy in Elderly
Qing Zhao,Jin Jun Luo +1 more
TL;DR: The epidemiology, pathophysiology, and clinical manifestations of elderly seizures are highlighted, including advanced aging, stroke, traumatic brain injury, dementia, neurodegenerative diseases, brain tumors, obstructive sleep apnea, and obesity.
Journal ArticleDOI
Posttraumatic Seizures in a Rural Nigerian Neurosurgical Service
TL;DR: Severe TBI and computed tomography findings of acute subdural hematoma and cerebral contusions are predictors of PTS in the authors' environment.
References
More filters
Journal ArticleDOI
Moderate and severe traumatic brain injury in adults.
TL;DR: New developments and current knowledge and controversies, focusing on moderate and severe TBI in adults, are summarised, with an emphasis on epidemiological monitoring, trauma organisation, and approaches to management.
Journal ArticleDOI
Epidemiology of Posttraumatic Epilepsy : A Critical Review
TL;DR: TBI is a major cause of epilepsy and the need to understand its frequency and its contribution to the total spectrum of the convulsive disorders is needed.
Journal ArticleDOI
Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis.
Paul M. Vespa,Chad Miller,David L. McArthur,Mathew Eliseo,Maria Etchepare,Daniel Hirt,Thomas C. Glenn,Neil A. Martin,David A. Hovda +8 more
TL;DR: The data suggest that post‐traumatic seizures represent a therapeutic target for patients with traumatic brain injury and increase in episodic as well as long‐lasting increases in intracranial pressure and microdialysis lactate/pyruvate ratio.
Journal ArticleDOI
Analyzing risk factors for late posttraumatic seizures: A prospective, multicenter investigation
Jeffrey Englander,Tamara Bushnik,Thao Duong,David X. Cifu,Ross Zafonte,Jerry Wright,R. E. Hughes,William Bergman +7 more
TL;DR: Englander et al. as mentioned in this paper performed a prospective, multicenter investigation to ascertain the natural history and to stratify risks for the development of late posttraumatic seizures in individuals with moderate to severe traumatic brain injury (TBI).
Journal ArticleDOI
Practice parameter: antiepileptic drug prophylaxis in severe traumatic brain injury: report of the Quality Standards Subcommittee of the American Academy of Neurology.
TL;DR: For adult patients with severe TBI, prophylaxis with phenytoin is effective in decreasing the risk of early post-traumatic seizures.