Safer Tripping: Serotonergic Psychedelics and Drug Checking. Submission and Detection Rates, Potential Harms, and Challenges for Drug Analysis
Tim Hirschfeld,Laura Smit-Rigter,Daan van der Gouwe,Simon Reiche,Heino Stöver,Tomislav Majić,Tomislav Majić +6 more
TLDR
In this article, the authors present the results of a literature search investigating the presence and proportion of serotonergic psychedelics (SPs) in drug checking (DC) samples.Abstract:
With the continuous emergence of new psychoactive substances, drug checking (DC) services are challenged by an increasingly complex drug market. Considering the resumed scientific and public interest in serotonergic psychedelics (SPs) like LSD, psilocybin, and 2C-B, we present the results of a literature search investigating the presence and proportion of SPs in DC samples. In 15 identified reports, submission and detection rates of SPs were comparably low, but increasing. Samples contained considerable amounts of adulterations or analogues, mostly novel SPs with unknown toxicological profiles and in some cases potentially life-threatening effects. The detection of SPs, however, requires advanced analysis techniques currently not available to most DC services. Given the substantial proportion of novel SPs in DC samples and the associated risks, DC can be a valuable harm reduction and monitoring tool for SPs if analysis techniques with high sensitivity are employed.read more
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Neuropsychological Functioning in Users of Serotonergic Psychedelics - A Systematic Review and Meta-Analysis.
TL;DR: The authors conducted a systematic review of studies investigating the neuropsychological performance in Serotonergic psychedelics (SPs) users, searching studies in Medline, Web of Science, embase, ClinicalTrials.gov, and EudraCT.
References
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Journal ArticleDOI
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action.
Franz X. Vollenweider,Margreet F. I. Vollenweider-Scherpenhuyzen,Andreas Bäbler,Helen Vogel,Daniel Hell +4 more
TL;DR: In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotics risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol.
Journal ArticleDOI
Poisoning Severity Score. Grading of Acute Poisoning
TL;DR: A Poisoning Severity Score has been developed and found applicable for grading the severity of poisoning and is intended to be an overall evaluation of the case, taking into account the most severe clinical features.
Journal ArticleDOI
Psychedelics and the essential importance of context.
Robin L. Carhart-Harris,Leor Roseman,Eline Haijen,David Erritzoe,Rosalind Watts,Igor Branchi,Mendel Kaelen +6 more
TL;DR: This article highlights the pharmacological mechanisms of classic psychedelics that it is believed render their effects exceptionally sensitive to context, and develops an evidence base for long-held assumptions about the critical importance of context in relation to psychedelic use that can help minimise harms and maximise potential benefits.
Journal ArticleDOI
Constructing drug effects: A history of set and setting:
TL;DR: Set and setting is a term which refers to the psychological, social, and cultural parameters which shape the response to psychedelic drugs as discussed by the authors, and it is considered fundamental to psychedelic rese...
Journal ArticleDOI
Psychedelics as Medicines: An Emerging New Paradigm
TL;DR: It is proposed that psychedelics exert therapeutic effects for psychiatric disorders by acutely destabilizing local brain network hubs and global network connectivity via amplification of neuronal avalanches, providing the occasion for brain network “resetting” after the acute effects have resolved.