Journal ArticleDOI
Sequence and Structural Features of Plant and Fungal Tyrosinases
TLDR
In this paper, a structure model for the active site of tyrosinases was proposed by using hemocyanin structure as a template, and the model was compared with respect to enzymatic structure, primary, secondary and tertiary structure, domain structure, Cu binding sites, maturation mechanism and activation mechanism.Abstract:
Tyrosinases from various organisms are compared with respect to enzymatic structure, primary, secondary and tertiary structure, domain structure, Cu binding sites, maturation mechanism and activation mechanism. On the basis of these comparisons, and by using hemocyanin structure as a template, a structure model for the active site of tyrosinases is proposed.read more
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Polyphenol oxidases in plants and fungi: going places? A review.
TL;DR: The more recent reports on polyphenol oxidase in plants and fungi are reviewed and many details about structure and probably function of PPO have been revealed, but some of the basic questions raised over the years remain to be answered.
Journal ArticleDOI
Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future.
Y.-J. Kim,Hiroshi Uyama +1 more
TL;DR: This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance, and examines the role of tyrosinase in melanin biosynthesis and its role in dermatological disorders.
Journal ArticleDOI
Physicochemical properties and function of plant polyphenol oxidase: a review'
Ruhiye Yoruk,Maurice R. Marshall +1 more
TL;DR: An overview of the current understanding of the reaction properties, biochemical characteristics and potential physiological roles of polyphenol oxidase (PPO)-catalyzed browning reactions are presented in this article.
Journal ArticleDOI
Functional Anthology of Intrinsic Disorder. 3. Ligands, Post-Translational Modifications, and Diseases Associated with Intrinsically Disordered Proteins
Hongbo Xie,Slobodan Vucetic,Lilia M. Iakoucheva,Christopher J. Oldfield,A. Keith Dunker,Zoran Obradovic,Vladimir N. Uversky +6 more
TL;DR: This work concludes the series of papers dedicated to the functional anthology of intrinsic disorder and describes approximately 80 Swiss-Prot functional keywords that are related to ligands, post-translational modifications, and diseases possessing strong positive or negative correlation with the predicted long disordered regions in proteins.
Journal ArticleDOI
Kinetics of mushroom tyrosinase inhibition by quercetin
Qing-Xi Chen,Isao Kubo +1 more
TL;DR: The inhibition mechanism obtained from Lineweaver-Burk plots show that quercetin is a competitive inhibitor, and the microscopic rate constants were determined for the reaction of quercETin with the enzyme.
References
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Journal ArticleDOI
Sequence and structural features of plant and fungal tyrosinases
TL;DR: A structure model for the active site of tyrosinases is proposed using hemocyanin structure as a template by comparing its structure with respect to enzymes, domain structure, Cu binding sites, maturation mechanism and activation mechanism.