J
Jamie H. D. Cate
Researcher at University of California, Berkeley
Publications - 207
Citations - 20743
Jamie H. D. Cate is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Ribosome & Translation (biology). The author has an hindex of 61, co-authored 196 publications receiving 18351 citations. Previous affiliations of Jamie H. D. Cate include University of California & Massachusetts Institute of Technology.
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Journal ArticleDOI
Crystal structure of the ribosome at 5.5 A resolution
Marat Yusupov,Gulnara Yusupova,Albion E. Baucom,Kate R. Lieberman,Thomas Earnest,Jamie H. D. Cate,Harry F. Noller +6 more
TL;DR: The crystal structure of the complete Thermus thermophilus 70S ribosome containing bound messenger RNA and transfer RNAs (tRNAs) at 5.5 angstrom resolution is described, suggesting coupling of the 20 to 50 angstrom movements associated with tRNA translocation with intersubunit movement.
Journal ArticleDOI
Structures of the bacterial ribosome at 3.5 Å resolution
Barbara S Schuwirth,Maria A. Borovinskaya,Cathy W Hau,Wen Zhang,Antón Vila-Sanjurjo,James M. Holton,Jamie H. D. Cate,Jamie H. D. Cate +7 more
TL;DR: Swiveling of the head of the small subunit observed in the present structures, coupled to the ratchet-like motion of the two subunits observed previously, suggests a mechanism for the final movements of messenger RNA and transfer RNAs during translocation.
Journal ArticleDOI
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
Jamie H. D. Cate,Anne R. Gooding,Anne R. Gooding,Elaine R. Podell,Elaine R. Podell,Kaihong Zhou,Barbara L. Golden,Barbara L. Golden,Craig E. Kundrot,Thomas R. Cech,Thomas R. Cech,Jennifer A. Doudna +11 more
TL;DR: The structure indicates the extent of RNA packing required for the function of large ribozymes, the spliceosome, and the ribosome.
Journal ArticleDOI
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
Alexandra East-Seletsky,Mitchell R. O’Connell,Spencer C. Knight,David Burstein,Jamie H. D. Cate,Jamie H. D. Cate,Robert Tjian,Jennifer A. Doudna +7 more
TL;DR: It is shown that bacterial C2c2 possesses a unique RNase activity responsible for CRISPR RNA maturation that is distinct from its RNA-activated single-stranded RNA degradation activity.
Journal ArticleDOI
The Path of Messenger RNA through the Ribosome
TL;DR: Using X-ray crystallography, this work directly observed the path of mRNA in the 70S ribosome in Fourier difference maps at 7 A resolution, finding that at the interface, only about eight nucleotides are exposed, and bond almost exclusively to 16S rRNA.