Journal ArticleDOI
Serum mediated inhibition of cellular immunity to methylcholanthrene-induced murine sarcomas.
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Serum from the tumor-bearing animals, obtained at the time of tumor removal and explantation into culture, abrogated the inhibitory effect of autochthonous lymph node cells (LNC), and serum taken before palpable tumors could be detected did not abrogate the inhibitedory LNC effect.About:
This article is published in Cellular Immunology.The article was published on 1970-05-01. It has received 187 citations till now. The article focuses on the topics: Cellular immunity & Methylcholanthrene.read more
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Journal ArticleDOI
Demonstration of cell-mediated immunity to human neoplasms of various histological types.
TL;DR: Evidence indicating antigenic cross‐reactivity between tumors of the same histological type was obtained for the following seven groups of neoplasms: malignant melanomas, carcinomas of the colon, breast, testis, endometrium and ovary, and various sarcomas.
Book ChapterDOI
Lymphocyte-Mediated Cytotoxicity And Blocking Serum Activity To Tumor Antigens
TL;DR: The studies reviewed in the chapter have given a relatively large amount of evidence for various cell-mediated and humoral immunological reactions against growing tumors, and at least some of the reactions observed in vitro appear to be able to influence tumor growth in vivo.
Journal ArticleDOI
Occurrence of malignancy in immunodeficiency diseases. A literature review.
Richard A. Gatti,Robert A. Good +1 more
TL;DR: In light of recent studies demonstrating both immunologically aggressive lymphocytes and the presence of blocking antibodies in the blood of neuroblastoma patients, a major role for immunity in ontogenesis seems almost certain.
Journal Article
Serotherapy of a Patient with a Monoclonal Antibody Directed against a Human Lymphoma-associated Antigen
Lee M. Nadler,Philip Stashenko,Russell Hardy,William D. Kaplan,Lawrence N. Button,Donald Kufe,Karen H. Antman,Stuart F. Schlossman +7 more
TL;DR: Preliminary evidence for the lack of clinical toxicity of a monoclonal antibody is provided and circulating blocking antigens as a significant obstacle to serotherapy are identified.
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Journal ArticleDOI
The fine structure of methylcholanthrene-induced tumors in mice.
TL;DR: Tumors of the primary host, tumors of the first transplant generation, and tumor cells grown in vitro had similar fine structure and rhabdomyoblasts, containing bundles of striated myofilaments, were seen in varying degrees of differentiation.