Silver Sulfadiazine: In Vitro Antibacterial Activity
TLDR
It is suggested that silver sulfadiazine may be useful as a broad-spectrum antimicrobial substance for the prevention and treatment of infections of burns and wounds.Abstract:
Isolates (657) representing 22 bacterial species were tested for susceptibility to silver sulfadiazine. All of the strains tested were inhibited by concentration levels of the drug which are easily achieved topically. It is suggested that silver sulfadiazine may be useful as a broad-spectrum antimicrobial substance for the prevention and treatment of infections of burns and wounds.read more
Citations
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Book ChapterDOI
Antimicrobial activity and action of silver
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TL;DR: This chapter discusses antimicrobial activity and action of silver, one of the native metals and second only to gold in its stability amongst the metals of antiquity, and its salts and complexes with proteins and other macromolecules.
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Microbiological and Clinical Aspects of Infection Associated with Stenotrophomonas maltophilia
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Prevention of Central Venous Catheter-Related Bloodstream Infection by Use of an Antiseptic-Impregnated Catheter: A Randomized, Controlled Trial
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Silver. I: Its antibacterial properties and mechanism of action.
TL;DR: The main mechanism of action of silver products, which are broad-spectrum antibiotics and are not yet associated with drug resistance, is described.
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Electrically Generated Silver Ions: Quantitative Effects on Bacterial and Mammalian Cells
TL;DR: The inhibitory and bactericidal concentrations of electrically generated silver ions were 10 to 100 times lower than for silver sulfadiazine, and effects on normal mammalian cells were minimal.
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TL;DR: Pseudomonas aeruginosa (Bacillus pyocyaneus) is normally an organism of low invasiveness and virulence, frequently noted as a local inhabitant of burns, surgical wounds and the genitourinary tract, but under suitable host conditions, this gram-negative, motile rod can assume the role of a life-threatening pathogen.
Journal Article
Control of pseudomonas infection in burns by silver sulfadiazine.
Fox Cl,Rappole Bw,Stanford W +2 more
Journal ArticleDOI
Silver Sulfadiazine: Effect on the Growth and Metabolism of Bacteria
TL;DR: In this paper, the addition of silver sulfadiazine (AgSu) to purified deoxyribonucleic acid (DNA) results in the formation of AgSu-DNA complexes, no such complexes were detected in bacteria treated with AgSu.
Silver Sulfadiazine: Effect on theGrowthand Metabolism ofBacteria
TL;DR: Radioactive AgSu was localized mainly in the cytoplasmic membrane fraction of treated cells and blocked macromolecular syntheses in treated bacteria, DNA synthesis being slightly more sensitive to this inhibitory action.
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