Journal ArticleDOI
Skin collagen biosynthesis in patients with rheumatoid arthritis treated with D-penicillamine.
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TLDR
It is suggested that the clinical improvement induced by D-penicillamine could reflect an inhibition of collagen proliferation in the synovium, and both collagen and general protein synthesis were inhibited in vitro.Abstract:
Collagen biosynthesis was measured in skin biopsies taken from 13 patients with rheumatoid arthritis before and after at least 6 months' continuous treatment with D-peniciilamine, 1.0 g/day. There was a significant 36% reduction in mean collagen biosynthesis (p<0.0125) as assayed by 14C-hydroxyproline formation from 14C-proline during 24 h of tissue culture. The changes in 14C-hydroxy-proline formation were correlated with the total doses of D-penicillamine taken (r=0.71, p<0.01) and the falls in ESR (r=0.72, p<0.01). No significant change in general protein synthesis was observed. 500 μg/mlD-penicillamine added to skin cultures in vitroinhibited both collagen and general protein synthesis (p<0.01). It is suggested that the clinical improvement induced by D-penicillamine could reflect an inhibition of collagen proliferation in the synovium.read more
Citations
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Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature.
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Effects of perioperative antiinflammatory and immunomodulating therapy on surgical wound healing.
Anthony J. Busti,Anthony J. Busti,Justin S. Hooper,Justin S. Hooper,Christopher J. Amaya,Salahuddin Kazi,Salahuddin Kazi +6 more
TL;DR: Clinicians must carefully evaluate individual patient risk factors, disease severity, and the pharmacokinetic properties and biologic effects of available therapies when weighing the risks and benefits of discontinuing therapy in the perioperative setting.
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Medical and surgical therapies for keloids
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Keloids and hypertrophic scars: review and treatment strategies.
TL;DR: Clinical, histopathological, and biochemical features of keloids and hypertrophic scars, as well as treatment guidelines, are discussed.
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Penicillamine: Review and cutaneous manifestations
TL;DR: D-Penicillamine, a heavy metal chelator used in the treatment of Wilson's disease and other conditions, may be associated with both noncutaneous and cutaneous side effects.
References
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Journal ArticleDOI
Modified procedure for the assay of H3- or C14-labeled hydroxyproline
Kale Juva,Darwin J. Prockop +1 more
TL;DR: Although the present procedure measures total radioactive hydroxyproline rather than the specific radioactivity of hydroxy Proline, it is more readily applicable to samples from a variety of sources.
Journal ArticleDOI
Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST
TL;DR: Cultures of dividing skin fibroblasts from normal and sclerodermatous human skin have permitted estimations of soluble collagen concentration, net collagen accumulation, cell-doubling times, and the comparison of morphologic and ultrastructural characteristics, but clues to the nature of the biologic defect in the regulation or activation of collagen synthesis by the sclerosis fibroblast are not provided.
Journal ArticleDOI
A defect in the intramolecular and intermolecular cross-linking of collagen caused by penicillamine. II. Functional groups involved in the interaction process.
Kalindi Deshmukh,Marcel E. Nimni +1 more
TL;DR: It is postulated that the inhibition of cross-linking caused by penicillamine in vivo and in vitro involves a reversible interaction with the aldehydes present in tropocollagen to form a thiazolidine type complex, since compounds with adjacent free sulfhydryl and amino groups are necessary for activity.
Journal ArticleDOI
Biosynthesis and maturation of skin collagen in scleroderma, and effect of D-penicillamine.
TL;DR: Analysis of skin collagen from patients with active scleroderma revealed the presence of a high proportion of reducible aldimine bond cross-links, which establishes that new collagen is being laid down in the skin.
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