scispace - formally typeset
Open AccessBook

Solid state chemistry of drugs

Stephen R. Byrn
About: 
The article was published on 1982-01-01 and is currently open access. It has received 1082 citations till now.

read more

Citations
More filters
Journal ArticleDOI

Characteristics and Significance of the Amorphous State in Pharmaceutical Systems

Bruno C. Hancock, +1 more
- 01 Jan 1997 - 
TL;DR: The amorphous state is critical in determining the solid-state physical and chemical properties of many pharmaceutical dosage forms and some of the most common methods that can be used to measure them are described.
Book ChapterDOI

Crystalline Polymorphism of Organic Compounds

Mino R. Caira
- 01 Jan 1998 - 
TL;DR: A wide variety of techniques appropriate to the study of organic crystalline polymorphism and pseu-dopolymorphism is then surveyed, ranging from simple crystal density measurement to observation of polymorphic transformations using variable-temperature synchrotron X-ray diffraction methods.
Journal ArticleDOI

Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates.

Nicholas Blagden, +3 more
- 30 Jul 2007 - 
TL;DR: The concept and theory of crystal engineering is covered and the potential benefits, disadvantages and methods of preparation of co-crystals, metastable polymorphs, high-energy amorphous forms and ultrafine particles are discussed.
Journal ArticleDOI

Strategies to Address Low Drug Solubility in Discovery and Development

Hywel David Williams, +6 more
- 01 Jan 2013 - 
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Journal ArticleDOI

High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids

Sherry L. Morissette, +8 more
- 23 Feb 2004 - 
TL;DR: The impact of form diversity encompasses issues of stability and bioavailability, as well as development considerations such as process definition, formulation design, patent protection and regulatory control.