Open AccessJournal Article
Some 3-hydrazono-2-indolinones and N-Mannich bases as potential anticonvulsants
TLDR
In this article, a new series of 3-aryloxy/arylthioxyacetylhydrazono-2-indolinones obtained by condensation of isatin with aryloxy/arythioxiacetyl hydrazines were treated with morpholine and formaldehyde.Abstract:
In this study a new series of 3-aryloxy/arylthioxyacetylhydrazono-2-indolinones obtained by condensation of isatin with aryloxy/arythioxyacetylhydrazines were treated with morpholine and formaldehyde to yield 1-morpholinomethyl-3-aryloxy/arylthioxyacetylhydrazono-2- indolinones. Structures of all the compounds were assigned on the basis of spectral data (UV, IR, 1H-NMR, EIMS) and elemental analyses. Anticonvulsant evaluation of the compounds revealed varying degrees of activity against pentylenentetrazole induced seizures.read more
Citations
More filters
Journal Article
Biological activities of isatin and its derivatives.
TL;DR: Isatin showed cardioinhibitory effect on frog heart, and hypotensive, respiratory depression and antidiuretic effects, and substituted indolinones showed antitubercular activity against M. tuberculosis H37Rv with MIC ranging from 10-20 microg mL(-1).
Journal ArticleDOI
Synthesis, characterization and pharmacological properties of some 4-arylhydrazono-2-pyrazoline-5-one derivatives obtained from heterocyclic amines
TL;DR: In vitro antituberculosis activity of 4-arylhydrazono-2-pyrazoline-5-ones 7-12, 14-24, 22a and coupling products 6a-f were tested on Mycobacterium tuberculosis H37Rv and 24, which exhibited > 90% inhibition in the primary screen, was re-examined for determination of its actual MIC.
Journal ArticleDOI
Synthesis and primary cytotoxicity evaluation of 3-[[(3-phenyl-4(3H)-quinazolinone-2-yl)mercaptoacetyl]hydrazono]-1H-2-indolinones.
Aysel Gürsoy,Nilgün Karalı +1 more
TL;DR: 3-[[(6-Chloro-3-phenyl-4(3H)-quinazolinone-2-yl)mercaptoacetyl]hydrazono]-5-fluoro-1H- 2-indolinone 5o showed the most favourable cytotoxicity against a renal cancer cell line UO-31.
Journal ArticleDOI
Synthesis and primary cytotoxicity evaluation of new 5-nitroindole-2,3-dione derivatives.
TL;DR: The most active compound was found to be 1-morpholinomethyl-5-nitroindole-2,3-dione-3-N-(chlorophenyl)thiosemicarbazone (4l), which demonstrated the most marked effects in the National Cancer Institute's 60 human tumour cell line in vitro screen on a non-small cell lung cancer cell line.
Journal ArticleDOI
Antifungal evaluation of bis Mannich bases derived from acetophenones and their corresponding piperidinols and stability studies.
TL;DR: B bis Mannich bases B1, B2, B4, and B5 appear to have potential for developing novel antifungal agents against dermatophytes, and thiol alkylation may contribute to the antIFungal activity.