Journal ArticleDOI
Splenic function: normal, too much and too little.
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TLDR
This review is concerned with normal splenic function, mechanisms and consequences of splenomegaly, hypersplenism, the medical indications for splenectomy and the various aspects of hyposplenist.About:
This article is published in The American Journal of Medicine.The article was published on 1979-02-01. It has received 149 citations till now. The article focuses on the topics: Splenectomy.read more
Citations
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Hyposplenism: a comprehensive review. Part I: basic concepts and causes.
TL;DR: In splenectomized, and functionally hyposplenic subjects, the pneumococcal conjugate vaccine is more effective, because it utilizes a T cell dependent mechanism, and should be the preferred vaccine in these circumstances.
Journal ArticleDOI
Haemophilus influenzae Infections in Adults: Characterization of Strains by Serotypes, Biotypes, and β-Lactamase Production
Richard J. Wallace,Daniel M. Musher,Edward Septimus,J. E. McGowan,F. J. Quinones,K. Wiss,P. H. Vance,P. A. Trier +7 more
TL;DR: When serotyping is carefully performed, nontypable organisms appear to be the major cause of invasive H. influenzae disease in adults.
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Hemolytic anemia due to warm autoantibodies
TL;DR: Rituximab, intravenous immunoglobulin, immunosuppressive drugs and danazol have been effective in refractory cases and for patients who are poor candidates for surgery.
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Complications of splenectomy.
Ali Cadili,Chris de Gara +1 more
TL;DR: The evidence relating to the effects of splenectomy on infection, malignancy, thrombosis, and transplantation is reviewed.
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Splenectomy: Indications, hazards and alternatives
M. J. Cooper,R. C. N. Williamson +1 more
References
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Dietary fat and dietary sugar in relation to ischaemic heart-disease and diabetes.
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The natural history of agnogenic myeloid metaplasia (AMM) and a critical evaluation of its relationship with the myeloproliferative syndrome.
Harry P. Ward,Matthew H. Block +1 more
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Red cells coated with immunoglobulin G: binding and sphering by mononuclear cells in man.
TL;DR: It is inferred that mononuclear cells have specific surface receptors for immunoglobulin G and that these provide a critical phase of the mechanism in vivo, whereby red cells or other particles coated with antibody are apprehended and destroyed.
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Antigens in immunity. XII. Antigen trapping in the spleen.
TL;DR: The tentative conclusion is reached that follicular antigen in a primary follicle encounters natural antibody on the surface of certain antigen-reactive lymphocytes, and the resultant reaction causes blast cell transformation and eventually the genesis of a germinal center.
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Functional asplenia in sickle-cell anemia.
TL;DR: Observation of Howell—Jolly bodies in the blood of children with sickle-cell anemia suggested the paradox of splenic hypofunction despite clinical splenomegaly, which may be a pertinent factor in the susceptibility to infections that is characteristic of this disease.
Related Papers (5)
Splenic studies. I. Susceptibility to infection after splenectomy performed in infancy.
Harold King,Harris B. Shumacker +1 more