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State-estimators for chemical reaction networks of Feinberg-Horn-Jackson zero deficiency type

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TLDR
In this article, the authors provide a necessary and sufficient condition for detectability of observers, and an explicit construction of observers when this condition is satisfied, for chemical reaction networks of the Feinberg-Horn-Jackson zero deficiency type.
Abstract
One of the most interesting questions in control theory is that of constructing observers. Observers compute estimates of the internal states of a dynamical system, using data provided by measurement probes or partial state information. For linear systems, Luenberger observers (also known as "deterministic Kalman filters" since they amount to Kalman filters designed without regard to the statistics of measurement noise) provide a general solution, but, for nonlinear systems, establishing generally applicable conditions for existence and convergence of observers is an open and active area of research. This paper provides a necessary and sufficient condition for detectability, and an explicit construction of observers when this condition is satisfied, for chemical reaction networks of the Feinberg-Horn-Jackson zero deficiency type.

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References
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Journal ArticleDOI

Smooth stabilization implies coprime factorization

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Journal ArticleDOI

On characterizations of the input-to-state stability property

TL;DR: In this paper, the Lyapunov sufficient condition for "input-to-state stability" (ISS) is also shown to be necessary and sufficient, which is an open question raised by several authors.
Book

On-Line Estimation and Adaptive Control of Bioreactors

TL;DR: The general dynamical model of bioreactors was extended to include extended Luenberger and Kalman observers and asymptotic observers for state estimation when the reaction rates are unknown, and a general solution to the linearizing control problem for a class of CST bioreacts was found.
Journal ArticleDOI

Kinetic proofreading in T-cell receptor signal transduction.

TL;DR: A model for the T-cell receptor is proposed in which this feature greatly enhances the receptor's ability to discriminate between a foreign antigen and self-antigens with only moderately lower affinity, a form of kinetic proofreading, known to be essential for the fidelity of protein and DNA synthesis.
Journal ArticleDOI

Correction to "Structure and stability of certain chemical networks and applications to the kinetic proofreading model of T-cell receptor signal transduction"

TL;DR: In this article, the theory of structure, stability, robustness, and stabilization for nonlinear systems has been studied for T-cell receptor signal transduction, and the theoretical conclusions are illustrated through an application to the kinetic proofreading model proposed by McKeithan (1995) for T -cell receptor transduction.
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