Stereoselective Addition of Organocopper Reagents to Cyclic N-Acyliminium Ions.
Catarina Ludwig,Lars-G. Wistrand,J. N. Keen,J. F. Allen,Claus J. Nielsen,A. J. Kondow,Kirpal S. Bisht,Virinder S. Parmar,George W. Francis +8 more
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This article is published in Acta Chemica Scandinavica.The article was published on 1994-01-01 and is currently open access. It has received 21 citations till now.read more
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New developments in the chemistry of N-acyliminium ions and related intermediates.
W. Nico Speckamp,M. J. Moolenaar +1 more
Journal ArticleDOI
Synthesis of bridged azabicyclic structures via ring-closing olefin metathesis.
TL;DR: A new strategy for the facile synthesis of azabicyclo[m.n.1]alkenes has been developed that involves the ring-closing metathesis (RCM) reaction of cis-2,6-dialkenyl-N-acyl piperidine derivatives, which may serve as a useful intermediate in syntheses of several Sarpagine alkaloids.
Journal ArticleDOI
Synthesis of functionally diverse bicyclic sulfonamides as constrained proline analogues and application to the design of potential thrombin inhibitors
TL;DR: A sulfonamide counterpart of an indolizidinone 2-carboxylic acid was synthesized and evaluated for its activity against the enzyme thrombin.
Journal ArticleDOI
Rhodium-Catalyzed Cyclohydrocarbonylation: Application to the Synthesis of (+)-Prosopinine and (−)-Deoxoprosophylline†
Iwao Ojima,Ephraim S. Vidal +1 more
TL;DR: These two short total syntheses clearly demonstrate the usefulness of the extremely regioselective cyclohydrocarbonylation process developed in these laboratories for the concise syntheses of piperidine alkaloids and related compounds.
Journal ArticleDOI
Stereocontrolled total synthesis of (--)-kaitocephalin.
TL;DR: This paper describes the successful implementation of a stereocontrolled strategy for the total chemical synthesis of the pyrrolidine-based alkaloid (--)-kaitocephalin that profits from the strategic utilization of substrate-controlled manipulations for the iterative installation of the requisite stereogenic centers.
Related Papers (5)
Stereoselective addition of grignard-derived organocopper reagents to n-acyliminium ions : synthesis of enantiopure 5- and 4,5-substituted prolinates
Chirospecific synthesis of trans-2,5-disubstituted pyrrolidines via stereoselective addition of organocopper reagents to N-acyliminium ions.
Lars-G. Wistrand,Marco Skrinjar +1 more