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Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics
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This article is published in Tetrahedron.The article was published on 1997-09-22. It has received 577 citations till now. The article focuses on the topics: Amino acid & Peptide.read more
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Biomedical Importance of Indoles
Nagendra Kumar Kaushik,Neha Kaushik,Pankaj Attri,Naresh Kumar,Chung Hyeok Kim,Akhilesh K. Verma,Eun Ha Choi +6 more
TL;DR: Some of the relevant and recent achievements in the biological, chemical and pharmacological activity of important indole derivatives in the areas of drug discovery and analysis are covered.
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New developments in the chemistry of N-acyliminium ions and related intermediates.
W. Nico Speckamp,M. J. Moolenaar +1 more
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Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes
TL;DR: A new classification of peptidomimetics (classes A–D) is introduced that enables a clear assignment of available approaches for the structure-based design of PPI inhibitors through stabilizing or mimicking turns, β-sheets, and helices.
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Peptidomimetics, a synthetic tool of drug discovery
TL;DR: The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field and recent advances in the synthesis of conformationally restricted building blocks and peptide bond isosteres are discussed.
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Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization.
TL;DR: This review focuses on modified peptides in which the peptide character is still preponderant, with particular emphasis on the chemical methodologies utilized to introduce the modifications.
References
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Synthesis and Applications of Small Molecule Libraries.
TL;DR: Thompson et al. as mentioned in this paper developed a method for the generation of large combinatorial libraries of peptides and oligonucleotides that are then screened against a receptor or enzyme to identify high affinity ligands or potent inhibitors, respectively.
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Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.
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Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.
TL;DR: Examples of hydrogen‐bonded, nonhelical conformations which occur in peptides and proteins are discussed—e.g., in cyclohexaglyeyl, an open tetrapeptide Gly‐L‐Pro‐ L‐Leu‐Gly, and in parts of the lysozyme chain.
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Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions.
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Peptidomimetics—Tailored Enzyme Inhibitors†
TL;DR: Rational design is advancing rapidly, and it is already clear that developments in the area of peptidomimetics have given a great boost to peptide chemistry as a whole, and this can be expected to continue, so that in future peptide Chemistry may be characterized by a type of symbiotic alliance between peptides and non-peptides.