Journal ArticleDOI
Structure of rat ultimobranchial bodies after birth.
TLDR
The evolution of ultimobranchial bodies in Holtzman rats during the first 64 weeks after birth was studied by reconstructing three‐dimensional models from serial sections stained by the periodic acid‐Schiff technique and the possibility that the ultimOBranchial parenchyma may function as an endocrine gland of holocrine type are discussed.Abstract:
The evolution of ultimobranchial bodies in Holtzman rats during the first 64 weeks after birth was studied by reconstructing three-dimensional models from serial sections stained by the periodic acid-Schiff technique. Radioautography with 125I was made to see if ultimobranchial cells and/or follicular cells lining the lumen of mixed follicles were able to iodinate proteins. The term ultimobranchial body designates herein an embryonic vesicular structure (derived from the third pharyngeal pouch) whose wall is made of a stratified squamous epithelium. During the first week after birth, the vesicular ultimobranchial body elongates rapidly and becomes a canal or a duct. During the second week, cell desquamation brings about local dilatations in the lumen of these ducts; with further enlargement ultimobranchial follicles will appear. In one-day-old rats, mixed follicles are present. Only the follicular component of mixed follicles iodinates proteins as is shown by radioautography. The reconstructed models enlarge rapidly up to the 56th day after birth at which time their weight has increased nineteenfold. These same models show that the three morphological components of ultimobranchial parenchyma, namely ducts, follicles and mixed follicles, are in continuity within the thyroid parenchyma. The formation of new thyroid follicles after birth and the possibility that the ultimobranchial parenchyma may function as an endocrine gland of holocrine type are discussed.read more
Citations
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Journal ArticleDOI
Solid cell nests of the thyroid: Light microscopy and immunohistochemical profile
José Cameselle-Teijeiro,Juan Varela-Durán,Clara Sambade,Javier P. Villanueva,Ramon Varela-Nunez,Manuel Sobrinho-Simões +5 more
TL;DR: The unusual association of adipose tissue and cartilage as well as the results of the extended immunohistochemical study in this series provides further support to the belief that SCNs and "mixed thyroid follicles" represent remnants of the ultimobranchial body and should be considered normal components of the thyroid gland.
Journal ArticleDOI
The relation between solid cell nests and C cells of the thyroid gland
TL;DR: The lack of disturbances in the calcium metabolism of the patients and the absence of medullary carcinoma in their family histories led us to interpret locally confined C-cell hyperplasia not as reactive nor premalignant, but rather as normal.
Journal ArticleDOI
Thyrocyte integration, and thyroid folliculogenesis and tissue regeneration: perspective for thyroid tissue engineering.
TL;DR: The understanding of the mechanistic basis of folliculogenesis is prerequisite for generation of artificial thyroid tissue, which would enable a more physiological strategy to the treatment of hypothyroidism caused by various diseases and surgical processes than conventional hormone replacement therapy.
Journal ArticleDOI
Cellular integration of thyrocytes and thyroid folliculogenesis: a perspective for thyroid tissue regeneration and engineering.
TL;DR: The understanding of the mechanistic basis of folliculogenesis is prerequisite for establishment of an artificial thyroid tissue, which would enable a more physiological approach to the treatment of hypothyroidism caused by various diseases and surgical processes than conventional hormone replacement therapy.
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Journal ArticleDOI
Induction of thyroid tumors in rats by a low iodine diet.
A. A. Axelrad,C. P. Leblond +1 more
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