Studien über pathogene Staphylokokken in südosteuropäischen und mediterranen geographischen Einheiten: 3. Mitteilung. Über die Verbreitung Penicillin-resistenter Staphylokokken

Carriage of phage patterns of pathogenic staphylococci in medical students.

Staphylococcal Studies in Hospital Staffs, II. Penicillin Resistance Determinations.

At the present time biological assay methods are the sole means of determining penicillin potency. A number of such methods are in use in various laboratories;1 however, the Oxford cup method,2 with several modifications,3 has continued to be regarded as a procedure in which a commensurate accuracy and speed may be obtained with a minimum of labor. The following filter paper disc modification should reduce the labor and time involved in setting up this test, while the case with which extra replicates may be run should increase the test's accuracy.The principal modification lies in the use of a thick filter paper disc saturated with the penicillin sample, substituted for the sample-containing small cylinder used in the Oxford cup method. These discs may be conveniently set up on the seeded plates at a rate of about 6 per minute, a rate considerably more rapid than that in the original method. Another advantage of the discs is that the test plates may be manipulated freely to facilitate reading. Experience ...

Filter Paper Disc Modification of the Oxford Cup Penicillin Determination.

incapacitated with pain for three months-was able to return to his work as a milk-roundsman for the rest of his life (nearly seven months) and die easily of a haemorrhage. He needed only one injection of 50 ml. of proctocaine. The ballet dancer, aged 46, died quietly of cardiac secondaries from cancer of the cervix uteri after two injections of 40 ml. of proctocaine, the second injection being fortified with 5 ml. of absolute alcohol, nine weeks after her first visit to us. The duration of relief with one to three injections varied in 11 others from three weeks to four months; in all but four this marked their natural term. The four developed painful secondaries in other regions, and one of them had a neurectomy for this reason. One other, a tough Welsh miner of wonderful physique with extensive invasion of the abdominal wall by a cancer of the bladder, died apparently from exhaustion and haemorrhage under thiopentone anaesthesia, given before attempting the caudal injection, as in no other way could the unfortunate man bear being turned on his side. This was our only disaster. Necropsy was refused, so that oil embolism could not be ruled out as the immediate cause of the sudden death shortly after the caudal injection was begun. He had suffered-hideous pain for some weeks before. Two women with pelvic secondaries from uterine cancer had apparently complete relief for a few days after injection, but on return of symptoms failed to be relieved by further injection. In one, intestinal obstruction by secondaries was proved at necropsy; in the other, massive abdominal and pulmonary secondaries proved fatal under opiates. One man with prostatic cancer was not relieved at all; radiography had revealed spinal metastases, and he was kept under morphine for the few weeks left. I have not observed or been told of any urinary or faecal incompetence following caudal injection of proctocaine, with or without added alcohol, in any of. the patients treated.

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Studien über pathogene Staphylokokken in südosteuropäischen und mediterranen geographischen Einheiten: 3. Mitteilung. Über die Verbreitung Penicillin-resistenter Staphylokokken

Citations

Carriage of phage patterns of pathogenic staphylococci in medical students.

Staphylococcal Studies in Hospital Staffs, II. Penicillin Resistance Determinations.

References

Filter Paper Disc Modification of the Oxford Cup Penicillin Determination.

Staphylococcal infection due to penicillin-resistant strains.

The carriage of Staphylococcus (ptogenes) aureus in man and its relation to wound infection

Coagulase‐positive staphylococci resistant to penicillin

Nose and skin carriage of Staphylococcus aureus in patients receiving penicillin.