Studies on the cytopathic effects of Newcastle disease virus: RNA synthesis in infected cells.
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Reeve et al. (1971) have shown that the ability of different Newcastle disease virus (NDV) strains to inhibit cellular protein synthesis is related directly to their virulence for cells in vitro and for eggs and chickens in vivo.Abstract:
Many viruses, in addition to the induction of c.p.e., produce profound biochemical alterations in the cell, particularly by the inhibition of cellular macromolecular synthesis (for review see Roizman & Spear, 1969). Reeve et al. (1971) have shown that the ability of different Newcastle disease virus (NDV) strains to inhibit cellular protein synthesis is related directly to their virulence for cells in vitro and for eggs and chickens in vivo.
Certain NDV strains can also inhibit cellular RNA synthesis, but the relationship of this property to the virulence of the infecting strain is not clear (Wheelock & Tamm, 1961; Scholtissek & Rott, 1965; Wilson, 1968). Moore, Lomniczi & Burke (1972) examined 13 strains of NDV but were unable to establish a relationship between virulence and the inhibition of host cell RNA synthesis.
The cell culture techniques and most of the virus strains have been described (Alexander, Reeve & Allan, 1970; Reeve & Poste, 1971).read more
Citations
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Genetics and Paragenetic Phenomena of Paramyxoviruses
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Aerosol vaccination against Newcastle disease using the Ulster strain.
R.E. Gough,W.H. Allan +1 more
TL;DR: It is suggested that primary vaccination of fully susceptible chickens with the Ulster strain will induce a high degree of immunity with less reaction in the respiratory tract than is found to occur with currently used vaccines.
Journal ArticleDOI
Modification of Newcastle disease virus release and cytopathogenicity in cells treated with plant lectins
TL;DR: It was proposed that binding of multivalent lectin molecules to the surface of infected cells impairs assembly of the virus envelope and the budding of new virus particles by the formation of cross-linkages and lattice formation between protein molecules on the cell surface.
Journal ArticleDOI
Studies on the Cytopathic Effects of Newcastle Disease Virus: the Cytopathogenicity of Strain Herts 33 in five Cell Types
TL;DR: The cytopathogenicity and production of Newcastle disease virus (NDV) strain Herts cultivated in chick embryo, baby hamster kidney, HEp-2, MDBK and L929 cells was investigated and the relationship of virus accumulation and virus release to the process of cell fusion is discussed.
References
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Journal ArticleDOI
Biochemical basis for alterations in structure and function of hela cells infected with newcastle disease virus
E. Frederick Wheelock,Igor Tamm +1 more
TL;DR: The ability of NDV-infected HeLa cells to synthesize DNA, protein, and RNA was investigated, and interference by NDV with the multiplication of influenza virus was probably due to the inhibitory effects ofNDV on cellular biosynthetic activities.
Journal ArticleDOI
Studies on the cytopathic effects of Newcastle disease virus: metabolic requirements.
TL;DR: Nine strains of Newcastle disease virus were examined for their ability to inhibit cellular protein synthesis and to cause cell fusion and neither virus-induced inhibition of cellularprotein synthesis nor cell fusion required new virus RNA synthesis, since azauridine did not affect these processes.
Journal ArticleDOI
Cell fusion by various strains of Newcastle disease virus and their virulence.
Alexander Kohn,Pinhas Fuchs +1 more
TL;DR: Some properties of eight strains of Newcastle disease virus (cell-fusing ability, hemolysin, heat stability of hemagglutinin or of Hemolysin) do not correlate with virulence of these strains.
Journal Article
Characterization and biological properties of the neuraminidase of strains of Newcastle disease virus which differ in virulence.
Book ChapterDOI
Chapter 3 Macromolecular Biosynthesis in Animal Cells Infected with Cytolytic Viruses
TL;DR: Not all viruses have been reported to affect host metabolism, but both abortive and productive infection nearly always cause some phenotypic modification of the cell.