Open AccessJournal Article
Study on Antidepressant Effect and Mechanism by Cyperus rotundus Extracts
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TLDR
In this article, the authors evaluated the effect of C.rotundus extracts on the 5-HT and DA in a swimming test and a tail suspension test and found that the ethyl acetate and n-butanol fractions from the ethanol extract significantly shortened immobility time.Abstract:
Objective:To screen the antidepressant fractions from Cyperus rotundus and investigate the possible a mechanism.Method: The extract and florentine were orally given to mice at a dosage of 10 g·kg-1 and 0.08 g·kg-1 per day,respectively.The swimming test and the tail suspension test were applied to observe the antidepressant effect of C.rotundus extracts.The content of serotonin(5-HT),dopamine(DA) and noradrenalin(NE) was determined by RP-HPLC method to study the mechanism of C.rotundus extracts.Result: The ethyl acetate and n-butanol fractions from the ethanol extract of C.rotundus significantly shortened immobility time in swimming test and the tail suspension test.The ethyl acetate and n-butanol fractions from the ethanol extract of C.rotundus markedly increased the content of 5-HT and DA with no action of NE.Conclusion: The ethyl acetate and n-butanol fractions from the ethanol extract of C.rotundus can produce an antidepressant effect,the mechanism of which may be related to affecting the 5-HT and DA nervous system.They may be the active part of C.rotundus.read more
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Journal ArticleDOI
Cyperus rotundus L.: Traditional uses, phytochemistry, and pharmacological activities.
Arslan Masood Pirzada,Hafiz Haider Ali,Muhammad Naeem,Muhammad Latif,Asad Hussain Bukhari,Asif Tanveer +5 more
TL;DR: The present paper summarizes the available information that will aid in future medicine preparation by identifying active ingredients and their mode of action for a specific therapeutic activity using the latest technologies to confirm the clinical activities and safety of this plant before being used for the development of new therapeutic agent in human subjects.
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Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery.
TL;DR: The antidepressant effect of certain TCMs are affirmative and encouraging, however, a lot of work needs to be done to evaluate the exact therapeutic effects and mechanisms of those active ingredients, specifically, to establish a unified standard for diagnosis and evaluation of curative effect.
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Rapid Antidepressant Activity of Ethanol Extract of Gardenia jasminoides Ellis Is Associated with Upregulation of BDNF Expression in the Hippocampus.
Hailou Zhang,Wenda Xue,Runjie Wu,Tong Gong,Weiwei Tao,Xin Zhou,Jingjing Jiang,Ying Zhang,Nan Zhang,Yi Cui,Chang Chen,Gang Chen +11 more
TL;DR: Ethanol extract of Yueju pill, a Traditional Chinese Medicine herbal formula widely used to treat mood disorders, demonstrates rapid antidepressant effects similar to ketamine, likely via instant enhancement of brain-derived neurotrophic factor expression in the hippocampus through upregulated, temporally linked with the antidepressant response.
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The effect of Chaihu-Shugan-San and its components on the expression of ERK5 in the hippocampus of depressed rats.
TL;DR: CSS aqueous extract has antidepressant-like effects on CUMS-induced depression model rats, and the antidepressant effect of CSS is greater than that of either the two separate components measured.
Journal ArticleDOI
Phenolic and iridoid glycosides from the rhizomes of Cyperus rotundus L.
Zhongliu Zhou,Hualin Zhang +1 more
TL;DR: Two new iridoid glycosides, rotunduside A (1) and rotundaide B (2), along with four known compounds, 6′-O-p-coumaroylgenipin gentiobioside (3), isoaragoside (4), chionoside A(5), and helioside C (6) were isolated from the rhizomes of Cyperus rotundaus L.
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