Subacute sclerosing panencephalitis - current perspectives.
TLDR
Subacute sclerosing panencephalitis is a progressive neurodegenerative disease that usually occurs 7–10 years after measles infection and is preventable by ensuring that an effective vaccine program for measles is made compulsory for all children younger than 5 years in endemic countries.Abstract:
Subacute sclerosing panencephalitis is a progressive neurodegenerative disease. It usually occurs 7–10 years after measles infection. The clinical course is characterized by progressive cognitive decline and behavior changes followed by focal or generalized seizures as well as myoclonus, ataxia, visual disturbance, and later vegetative state, eventually leading to death. It is diagnosed on the basis of Dyken’s criteria. There is no known cure for subacute sclerosing panencephalitis to date, but it is preventable by ensuring that an effective vaccine program for measles is made compulsory for all children younger than 5 years in endemic countries.read more
Citations
More filters
Journal ArticleDOI
Atypical Pediatric Demyelinating Diseases of the Central Nervous System.
Regina M. Troxell,Alison Christy +1 more
TL;DR: Atypical demyelinating disease may mimic classic neuroinflammatory diseases of the central nervous system and through careful history-taking and review of atypical MRI findings, patients may avoid misdiagnosis and mistreatment.
Journal ArticleDOI
Substantial Remission in Subacute Sclerosing Panencephalitis by Following the Ketogenic Diet: A Case Report.
TL;DR: KD has an anti-inflammatory effect and can halt and reverse neurodegenerative changes and its neuroprotective effects could be due to the reduced oxidative stress, enhanced mitochondrial activity, and the suppression of pro-apoptotic factors.
Journal ArticleDOI
Measles Induced Encephalitis: Recent Interventions to Overcome the Obstacles Encountered in the Management Amidst the COVID-19 Pandemic
Mufaddal Najmuddin Diwan,Sabagh Samad,Rabeea Mushtaq,Alifiya Aamir,Zoha Allahuddin,Irfan Ullah,Rifayat Ullah Afridi,Aneela Ambreen,Adel Khan,Nimra Ehsan,Zoia Ehsan Khattak,Antonio Ventriglio,Domenico De Berardis +12 more
TL;DR: The management of measles-induced encephalitis mainly revolves around prevention against contracting the disease and providing supportive care if acquired as discussed by the authors, which is the major means of preventing this disease in childhood.
Journal ArticleDOI
Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas
Pauline Samia,Katherine Oyieke,Dorcas S Tunje,Anaita Udwadia-Hegde,Kristen A. Feemster,Ibrahim Oncel,Banu Anlar +6 more
TL;DR: In this paper , the authors explore the current global status of SSPE, its treatment, and preventive measures, and elucidate on these approaches and their limitations, reasons for poor vaccine coverage in low and middle-income countries, as well as the possible solutions to the prevention of measles and eventual avoidance of sclerosing panencephalitis.
Journal ArticleDOI
Host Cell Restriction Factors of Paramyxoviruses and Pneumoviruses.
Rubaiyea Farrukee,Malika Ait-Goughoulte,Philippa M. Saunders,Sarah L. Londrigan,Patrick C. Reading +4 more
TL;DR: An outlook is provided regarding the landscape of emerging technologies and tools available to study host cell restriction factors, as well as the suitability of these proteins as targets for broad-spectrum antiviral therapeutics.
References
More filters
Journal ArticleDOI
Subacute Sclerosing Panencephalitis: More Cases of This Fatal Disease Are Prevented by Measles Immunization than Was Previously Recognized
William J. Bellini,Jennifer S. Rota,Luis Lowe,Russell S. Katz,Paul R. Dyken,Sherif R. Zaki,Wun-Ju Shieh,Paul A. Rota +7 more
TL;DR: It was determined that the development of SSPE was associated with the measles resurgence that occurred in the United States during 1989-1991, and the estimated risk of developing S SPE was 10-fold higher than the previous estimate reported for the United United States in 1982.
Journal ArticleDOI
Subacute sclerosing panencephalitis: an update.
TL;DR: Management of the disease includes seizure control and avoidance of secondary complications associated with the progressive disability, and trials of treatment with interferon, ribavirin, and isoprinosine using different methodologies have reported beneficial results.
Journal ArticleDOI
Review of the effect of measles vaccination on the epidemiology of SSPE
TL;DR: A comprehensive review of the impact of measles immunization on the epidemiology of SSPE and examined epidemiological evidence on whether there was any vaccine-associated risk was conducted in this paper.
Journal ArticleDOI
Cellular inclusions in cerebral lesions of epidemic encephalitis: second report
TL;DR: Encephalitis is a term which has been applied to a wide variety of diseases of the central nervous system, and the clinician uses it to designate an obscure, diffuse disease of the brain, whether of proved inflammatory nature or not.
Journal ArticleDOI
Subacute sclerosing panencephalitis.
TL;DR: There is no effective treatment to completely cure SSPE, but Oral isoprinosine and intrathecal or intraventricular alpha-interferon may prolong survival to some extent.