Journal ArticleDOI
Suction blisters for the investigation of radiation reactions in human skin.
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TLDR
The levels of type I and III aminoterminal (PINP and PIIINP, respectively) and type I carboxyterminal (PICP) procollagen propeptides were considerably increased in comparison with the non-irradiated control breast skin, 1–5 years after postmastectomy radiotherapy.Abstract:
(2002). Suction Blisters for the Investigation of Radiation Reactions in Human Skin. Acta Oncologica: Vol. 41, No. 3, pp. 313-314.read more
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Solar-simulated radiation induces secretion of IL-6 and production of isoprostanes in human skin in vivo
TL;DR: The differential expression and release of cytokines, and the extent of oxidative damage might therefore depend on the dose and regimen of exposure to solar-simulated radiation.
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Radiation-induced changes in skin type I and III collagen synthesis during and after conventionally fractionated radiotherapy.
Riitta Keskikuru,Arja Jukkola,Jouni Nuutinen,Vesa Kataja,Juha Risteli,Pekka Autio,Tapani Lahtinen +6 more
TL;DR: A maximum and elevated levels for PINP and PIIINP skin collagen metabolism determined from SBF are demonstrated during the 2 years' follow-up and correlated with the thickening of the skin and subcutaneous induration but not with erythema.
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UV radiation induces the release of angiopoietin‐2 from dermal microvascular endothelial cells
TL;DR: It is suggested that UVR triggers the release of endothelial Ang‐2 which may promote the destabilization and pro‐inflammatory phenotype of the microvascular endothelium and stimulating the Ang‐1 activity may represent a strategy to stabilize the dermal microcirculatory system, thus protecting against UVR‐induced skin damages.
References
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Journal ArticleDOI
Relationship between early and late normal-tissue injury after postmastectomy radiotherapy
Søren M. Bentzen,Marie Overgaard +1 more
TL;DR: Investigation of factors of importance in the development of telangiectasia in patients who received postmastectomy radiotherapy with two different fractionation schedules found patients who developed moist desquamation had a statistically significantly increased risk of developing telang iectasia after a specific course of radiotherapy.
Journal ArticleDOI
A New Method to Measure Type I and III Collagen Synthesis in Human Skin In Vivo: Demonstration of Decreased Collagen Synthesis After Topical Glucocorticoid Treatment
TL;DR: Measurement of collagen type specific propeptides in suction blisters can be used as an estimate of collagen synthesis in vivo, avoiding both local anesthesia and skin biopsing.
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Effects of an inhaled steroid (budesonide) on skin collagen synthesis of asthma patients in vivo.
TL;DR: Even a low dose of inhaled corticosteroid represses skin collagen synthesis within a relatively short period in patients with asthma on concentrations of procollagen propeptides in suction blister fluid reflectingskin collagen synthesis in vivo.
Journal ArticleDOI
The Influence of Skin Temperature on Dermal-Epidermal Adherence: Evidence Compatible with a Highly Viscous Bond
TL;DR: This type of relationship supports the hypothesis that epidermis and dermis are connected by a viscous bond and the strong influence of skin temperature suggests that a high viscosity is involved.
Journal ArticleDOI
Type I collagen turnover and cross-linking are increased in irradiated skin of breast cancer patients.
M.-L. Sassi,Arja Jukkola,Riitta Riekki,Matti Höyhtyä,Leila Risteli,Aarne Oikarinen,Juha Risteli +6 more
TL;DR: Radiotherapy induces a long-term increase in the turnover of type I collagen and leads to the accumulation of cross-linkedtype I collagen in skin.