A
Akimichi Morita
Researcher at Nagoya City University
Publications - 394
Citations - 9439
Akimichi Morita is an academic researcher from Nagoya City University. The author has contributed to research in topics: Psoriasis & Medicine. The author has an hindex of 46, co-authored 349 publications receiving 7727 citations. Previous affiliations of Akimichi Morita include University of Texas Southwestern Medical Center & University of Düsseldorf.
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Journal ArticleDOI
Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning.
Kiyoshi Ariizumi,Guo Liang Shen,Sojin Shikano,Shan Xu,Robert Ritter,Tadashi Kumamoto,Dale Edelbaum,Akimichi Morita,Paul R. Bergstresser,Akira Takashima +9 more
TL;DR: In vitro results suggest that dectin-1 on DC may bind to as yet undefined ligand(s) on T cells, thereby delivering T cell co-stimulatory signals.
Journal ArticleDOI
Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study.
Phoebe Rich,Bardur Sigurgeirsson,Diamant Thaçi,J.-P. Ortonne,Carle Paul,R. E. Schopf,Akimichi Morita,K. Roseau,Evita Harfst,Achim Guettner,Matthias Machacek,Charis Papavassilis +11 more
TL;DR: Background Interleukin (IL)‐17A has major proinflammatory activity in psoriatic lesional skin and its role in promoting wound healing is still under investigation.
Journal ArticleDOI
The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist.
Kazumitsu Sugiura,Akemi Takemoto,Michiya Yamaguchi,Hidetoshi Takahashi,Yukiko Shoda,Teruyuki Mitsuma,Kenshiro Tsuda,Emi Nishida,Yaei Togawa,Kimiko Nakajima,Akihiro Sakakibara,Shigeo Kawachi,Makoto Shimizu,Yasutomo Ito,Takuya Takeichi,Michihiro Kono,Yasushi Ogawa,Yoshinao Muro,Akemi Ishida-Yamamoto,Shigetoshi Sano,Hiroyuki Matsue,Akimichi Morita,Hitoshi Mizutani,Hajime Iizuka,Masahiko Muto,Masashi Akiyama +25 more
TL;DR: GPP alone is a distinct subtype of GPP and is etiologically distinguished from GPP with PV, and that the majority of G PP alone is caused by deficiency of the interleukin-36 receptor antagonist due to IL36RN mutations.
Journal ArticleDOI
Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy
Akimichi Morita,Thomas Werfel,Helger Stege,Constanze Ahrens,Karin Karmann,Markus Grewe,Susanne Grether-Beck,Thomas Ruzicka,Alexander Kapp,Lars-Oliver Klotz,Helmut Sies,Jean Krutmann +11 more
TL;DR: It is demonstrated that singlet oxygen is a potent trigger for the induction of human T cell apoptosis andSinglet oxygen generation is identified as a fundamental mechanism of action operative in phototherapy.
Journal ArticleDOI
Phase 2 Trial of Selective Tyrosine Kinase 2 Inhibition in Psoriasis.
Kim A. Papp,Kenneth B. Gordon,Diamant Thaçi,Akimichi Morita,Melinda Gooderham,Peter Foley,Ihab G. Girgis,Sudeep Kundu,Subhashis Banerjee +8 more
TL;DR: Selective inhibition of TYK2 with the oral agent BMS‐986165 at doses of 3 mg daily and higher resulted in greater clearing of psoriasis than did placebo over a period of 12 weeks.