Showing papers in "Radiotherapy and Oncology in 2001"

TL;DR: In tissues with a consequential component of the late sequelae, amelioration of the acute response to irradiation may be a useful approach to minimize late side effects of effective radiation therapy.

TL;DR: A large number of studies regarding patient set-up verification for treatments of patients with head and neck, prostate, pelvis, lung and breast cancer, as well as for mantle field/total body treatments are presented.

TL;DR: When IMRT was compared with conventional techniques, the dosimetric advantage of IMRT did translate into a significant reduction of late salivary toxicity in patients with oropharyngeal carcinoma.

TL;DR: The new set of tolerances and the quantity confidence limit have proven to be useful tools for the acceptance of photon beam dose calculation algorithms of treatment planning systems.

TL;DR: This review focuses almost exclusively on the skin manifestations of radiation recall to assemble the largest data base upon which to discuss this rare phenomenon.

TL;DR: In the absence of real-time pre-treatment imaging of prostate position, sequential portal films of implanted prostatic markers should improve quality assurance by confirming organ position within the treatment field over the course of therapy.

TL;DR: Thermoplastic masks provide an accurate patient immobilization at the shoulder level, and setup variations are reduced when 4 or 5 FP masks are used, which could be used for the assessment of margins for the PTV.

TL;DR: Adding MMF, a potent topical corticosteroid, to an emollient cream is statistically significantly more effective than emollsient cream alone in reducing acute radiation dermatitis.

TL;DR: A large interobserver variability in GTV delineation of brain tumors is demonstrated and a combination of the two image modalities is recommended for brain tumor delineation for treatment planning.

TL;DR: Systematic set-up errors have a dominant effect on the cumulative dose to the CTV and the gain of controlling breathing motion during irradiation is expected to be small and efforts should rather focus on minimizing systematic errors.

TL;DR: Fast neutron radiotherapy provides higher local control rates than a mixed beam and photons in advanced, recurrent or not completely resected adenoid cystic carcinoma of the major and minor salivary glands and can be recommended in patients with bad prognosis with gross residual disease, with unresectable tumors, or inoperable tumors.

TL;DR: It is demonstrated that the use of IM photons or protons both have the potential to reduce the possibility of spinal cord toxicity and 3D conformal therapy, although somewhat inferior in quality to protons or IM photons, has been shown to be a reasonable alternative to the more advanced techniques.

TL;DR: Patients with stage I or II disease have better overall and cause-specific survival than patients with stage III or IV disease, and radiation doses ranging from 15 to 30 Gy are achieved.

TL;DR: It was studied whether differences in acute radiosensitivity exist between parotid and submandibular/sublingual glands and the results revealed that salivary flow rates decreased dramatically during the first 2 weeks of radiotherapy.

TL;DR: The most favourable bRFR was observed for adjuvant therapy, and patients with palpable recurrence after radical prostatectomy require investigation of alternative salvage strategies.

TL;DR: Washing the irradiated skin during the course of radiotherapy for breast cancer is not associated with increased skin toxicity and should not be discouraged.

TL;DR: All patients undergoing adjuvant tangential breast RT in whom the heart is seen to be in the high-dose volume should be considered for the addition of cardiac-sparing lead blocks, as three-dimensional CT planning and alternative beam arrangements with IMRT optimization enables more complete cardiac sparing without compromise of PTV coverage in certain patients.

TL;DR: The rV90 seems to be the most useful and easily obtained parameter when comparing treatment plans to evaluate the risk of rectal morbidity and demonstrates a dose-volume relationship at the reference dose of 60 Gy ( approximately 90% of the prescribed dose) with respect to late rectal toxicity.

TL;DR: In this paper, the authors quantify the dependence of early reactions on the dose-fractionation used in radiotherapy and on patients' age and radiation field size, using linear regression to analyze the time with reactions in individual patients.

TL;DR: IMRT with a few carefully chosen field directions may lead to a modest reduction in pneumonitis, or allow tumour dose escalation within the currently accepted lung toxicity.

TL;DR: 3DCRT reduced normal tissue irradiation compared to conventional techniques, but did not improve PTV or spinal cord doses, and IMRT improved the PTV coverage and reduced the spinal cord dose.

TL;DR: The aim of the presented study is to correlate the information obtained with the two approaches for high dose-rate (HDR) brachytherapy of cervix carcinoma by comparing the mean values derived from computed tomography sections and 3D dose computation.

TL;DR: The results demonstrate that an underdosage of the PTV up to 20% may occur if calculated dose values are used for treatment planning, and the dose to the lung will be wrongly predicted which may influence the choice of the prescribed dose level in dose-escalation studies.

TL;DR: It appears worthwhile to try to identify, in follow-up examinations of patients after radiation therapy, what kind of processes might be involved in triggering subclinical residual injury to develop into a clinically manifest late effect.

TL;DR: Off-line verification protocols can be particularly effective in head and neck patients due to the smallness of the random set-up errors and the excellent set- up reproducibility that can be achieved with such protocols enables accurate dose delivery in conformal treatments.

TL;DR: Clinical features, treatment, survival and patterns of failure, gliosarcomas and GBM cannot be distinguished clinically and the same principles should be applied for the treatment of these tumors.

TL;DR: CA4DP enhanced radiation damage in the two tumor models without enhancing normal tissue damage and these radiation effects were clearly consistent with the anti-vascular action of CA4DP.

TL;DR: The current analysis shows the importance of a microscopic complete resection in a multi-modality approach with IORT for survival and local control and Salvage is rare for patients undergoing subtotal resection.

TL;DR: There is no reliable evidence to support the hypothesis that HBO2 therapy slows or reverses RIBP in a substantial proportion of affected individuals, although improvements in warm sensory threshold offer some suggestion of therapeutic effect.

TL;DR: This study showed an association between large bladder volumes and dose reductions, and the patients will be treated with a standardized bladder volume.