Survival and predictors of survival in patients with congestive heart failure due to Chagas' cardiomyopathy.
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TLDR
It is concluded that 50% of the patients with heart failure due to Chagas' disease die in 47 months and that &OV0622;O2max and EF are important indices of survival in this group.Abstract:
BACKGROUNDThe fundamental determinant of the natural history of Chagas' disease is cardiac involvementMETHODS AND RESULTSWe studied 104 male patients with congestive heart failure due to Chagas' disease to estimate the survival distribution function and to evaluate age, functional class (FC), maximal oxygen consumption (VO2max), and ejection fraction (EF) as predictors of survival Statistical evaluation was performed through univariate (Student's t test and chi 2 test) and multivariate analyses (Cox's regression model) Overall survival was 66% at 1 year, 56% at 3 years, and 48% at 5 years Ages were not statistically different (P = 9811) between survivor (403 +/- 87) and nonsurvivor (403 +/- 94) groups The ejection fraction(s) were statistically different (P = 0001) between survival (436 +/- 99) and nonsurvival (306 +/- 81) groups, as was VO2max (P = 0001) (210 +/- 47 and 150 +/- 49, respectively) Most of the surviving patients were in FC II and most of the nonsurvivors were in FC IV (read more
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Journal ArticleDOI
Evaluation and treatment of chagas disease in the United States : A systematic review
Caryn Bern,Susan P. Montgomery,Barbara L. Herwaldt,Anis Rassi,José Antonio Marin-Neto,Roberto Oliveira Dantas,James H. Maguire,Harry Acquatella,Carlos A. Morillo,Louis V. Kirchhoff,Robert H. Gilman,Pedro A. Reyes,Roberto Salvatella,Anne C. Moore +13 more
TL;DR: Despite gaps in the evidence base, current knowledge is sufficient to make practical recommendations to guide appropriate evaluation, management, and etiologic treatment of Chagas disease.
Journal ArticleDOI
Development and validation of a risk score for predicting death in Chagas' heart disease.
Anis Rassi,William C. Little,Sérgio Salles Xavier,Sérgio Gabriel Rassi,Alexandre Gabriel Rassi,Gustavo Gabriel Rassi,Alejandro Marcel Hasslocher-Moreno,Andréa Silvestre de Sousa,Mauricio Scanavacca +8 more
TL;DR: A simple risk score was developed to predict death in Chagas' heart disease and was validated in an independent cohort.
Journal ArticleDOI
Predictors of mortality in chronic Chagas disease: a systematic review of observational studies.
Anis Rassi,Sérgio Gabriel Rassi +1 more
TL;DR: A systematic review of published studies indicates that impaired left ventricular function, New York Heart Association class III/IV, cardiomegaly, and nonsustained ventricular tachycardia indicate a poor prognosis in patients with chronic Chagas disease.
Journal ArticleDOI
Myocardial delayed enhancement by magnetic resonance imaging in patients with Chagas' disease: a marker of disease severity.
Carlos E. Rochitte,Paulo F.M. Oliveira,Joalbo M. Andrade,Barbara Maria Ianni,José R. Parga,Luiz Francisco Rodrigues de Ávila,Roberto Kalil-Filho,Charles Mady,José Cláudio Meneghetti,Joao A.C. Lima,José Antonio Franchini Ramires +10 more
TL;DR: In Chagas' heart disease (CHD), MDE by MRI quantifies MF that not only can be detected in the early asymptomatic stages but parallels well-established prognostic factors and provides unique information for clinical disease staging.
Journal ArticleDOI
Statistical Methods for Survival Data Analysis
TL;DR: In this article, Statistical Methods for Survival Data Analysis (SVMDA) is used to analyze survival data in the context of statistical methods for survival data analysis (SDFA).
References
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Statistical Methods for Survival Data Analysis
TL;DR: The Fourth Edition of Statistical Methods for Survival Data Analysis is an ideal text for upper-undergraduate and graduate-level courses on survival data analysis and is an excellent resource for biomedical investigators, statisticians, and epidemiologists, as well as researchers in every field in which the analysis of survival data plays a role.
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TL;DR: This study followed up 182 patients with chronic left ventricular failure who were symptomatic despite therapy and found that the incidence of sudden death was similar in patients with coronary artery disease and idiopathic dilated cardiomyopathy.
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