Synthese du methyl-2 p-chlorophenyl-4 pentane diol-2,4(fenpentadiol) marque AU 14C†

TLDR: In this article, a psychotropic drug was obtained by means of the action of methyl magnesium iodure on p-chlorophenyl-3 hydroxy-3 ethyl butyrate 14C-3.

Abstract: Methyl-2 p-chlorophenyl-4 pentane diol 2,4 14C-4 (Rd 292-Fenpentadiol), a psychotropic drug, was prepared by means of the action of methyl magnesium iodure on p-chlorophenyl-3 hydroxy-3 ethyl butyrate 14C-3. The latter was obtained by means of the Reformatzri reaction between ethyl bromoacetate and p-chloroacetophenon 14CO, which was obtained by the action of iodhydric acid on p-chlorophenyl diazoacetophenon 14CO, resulting from the action of diazomethane on p-chlorobenzoyl 14C chlorure. The necessary p-chlorobenzoic carboxyl 14C acid was obtained through carbonatation of p-chlorphenyl magnesium bromure, free from any isomere a or m. The total yield compared to 14CO3Ba was 31% Specific activity : 25, 3 mCi/mM.