Journal ArticleDOI
Synthesis and anticonvulsant activity of 4-bromophenyl substituted aryl semicarbazones.
TLDR
The essential structural features responsible for interaction with receptor site are established within a suggested pharmacophore and three compounds showed greater protection than sodium valproate.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2000-10-01. It has received 139 citations till now.read more
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Anticonvulsant activity of Schiff bases of isatin derivatives.
TL;DR: N-methyl-5-bromo-3-(p-chlorophenylimino) isatin exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg(-1), showing better activity than the standard drugs phenytoin, carbamazepine and valproic acid.
Journal ArticleDOI
Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives.
TL;DR: The essential structural features responsible for interaction with receptor site are established within a suggested pharmacophore and all the active compounds showed greater protection than sodium valproate.
Journal ArticleDOI
Triazole incorporated thiazoles as a new class of anticonvulsants: design, synthesis and in vivo screening.
Nadeem Siddiqui,Waquar Ahsan +1 more
TL;DR: Various 3-[4-(substituted phenyl)-1,3-thiazol-2-ylamino]-4-dihydro-1H-1,2,4-triazole-5-thiones (7a-t) were designed keeping in view the structural requirements suggested in the pharmacophore model for anticonvulsant activity to display a wide margin of safety with Protective index, median hypnotic dose (HD(50)
Journal ArticleDOI
Synthesis of some 3-(arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazole derivatives and their anticonvulsant activity.
İlkay Küçükgüzel,Ş. Güniz Küçükgüzel,Sevim Rollas,Gülten Ötük-Sanış,Osman Özdemir,Ibrahim Bayrak,Tuncay Altug,James P. Stables +7 more
TL;DR: A series of novel 3-[[(substituted phenyl)methyl]thio]-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazoles 21-31 were synthesized for evaluation of their biological properties and some of the tested compounds showed marginal activity against M. tuberculosis H37 Rv.
Journal ArticleDOI
Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea
TL;DR: It can be concluded that newly synthesized compounds possessed promising CNS activities after screening for anticonvulsant, CNS depressant and sedative-hypnotic activity in mice.
References
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Journal ArticleDOI
Antiepileptic drug development: II. Anticonvulsant drug screening.
TL;DR: The Anticonvulsant Screening Project has evaluated the activity of 1,495 experimental compounds accessioned in the first 2 years, and preliminary data show that 430 of these compounds have good anticonVulsant activity.
Journal ArticleDOI
Antiepileptic Drug Mechanisms of Action
TL;DR: Established antiepileptic drugs (AEDs) decrease membrane excitability by interacting with neurotransmitter receptors or ion channels by inhibiting sodium channels, γ‐ami‐nobutyric acid type A (GABAA) receptors, or calcium channels.
Journal ArticleDOI
Antiepileptic Drug Development Program.
Roger J. Porter,James J. Cereghino,Gill D. Gladding,Bettiejean Hessie,Harvey J. Kupferberg,Barrett Scoville,B. G. White +6 more
TL;DR: The establishment of the Antiepileptic Drug Development Program, which encompasses both the preclinical and clinical elements of drug development, including the Anticonvulsant Screening Project, the Toxicology Project, and support for controlled clinical trials, is described.
Journal ArticleDOI
Some Aspects of Prognosis in the Epilepsies: A Review
TL;DR: Factors that may influence the prognosis of the epilepsies, including the problems of diagnosis, are reviewed and special emphasis is given to the issue of spontaneous remission and the question of prog outlook of different epileptic syndromes.