Journal ArticleDOI
Synthesis of 2-halo-4,5-difluorobenzoic acids
Braish Tamim F,Fox Darrell E +1 more
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This article is published in Organic Preparations and Procedures International.The article was published on 1991-10-01. It has received 7 citations till now. The article focuses on the topics: Halo.read more
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Journal ArticleDOI
Chemo- and regioselectivity in the reactions between highly electrophilic fluorine containing dicarbonyl compounds and amines. Improved synthesis of the corresponding imines/enamines
TL;DR: The results obtained lead to the development of a generalized and practical method for large-scale synthesis of the corresponding imines/enamines, useful starting materials for preparation fluorinated amines and amino acid.
Journal ArticleDOI
Preparation of 5-(2-Methoxy-4-nitrophenyl)oxazole: A Key Intermediate for the Construction of VX-497
TL;DR: In this article, a two-stage process for the multigram preparation of 5-(2-methoxy-4-nitrophenyl)oxazole, a key intermediate for the preparation of the hepatitis C drug candidate VX-497 (merimepodib), has been achieved in good yield from a commercially available dye.
OtherDOI
Fluorinated Aromatic Compounds
TL;DR: In this paper, the preparation, properties, reactions, and applications of three types of fluorinated aromatic compounds: ring-fluorinated aromatics, side-chain fluorinated aromatic and arylfluoroalkyl ethers, and fluorinated nitrogen heterocyclics.
Journal ArticleDOI
Synthesis of 2-Bromo-4, 5-Difluorobenzolc Acid
Braish Tamim F,Fox Darrell E +1 more
TL;DR: In this article, the synthesis of 2-bromo-4, 5-difluorobenzoic acid was achieved from diffluorophthalic anhydride by either using a Losen rearrangement or the Barton bromodecarboxylation reaction.
Reference EntryDOI
The Formation of the CF Bond: The Last Twelve Years
TL;DR: In this paper, the synthesis of compounds containing the 18F isotope for use in positron-emitting tomography (PET) has been described and compared with selective fluorination methods.
References
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Book
Modern Synthetic Reactions
TL;DR: The Modern Synthetic Reactions as discussed by the authors is a book about modern organic synthesis with a focus on the use of continuous flow reactors, which is a tool for the modern synthesis of organic compounds.
Journal ArticleDOI
Alkyl nitrite-metal halide deamination reactions. 6. Direct synthesis of arenediazonium tetrafluoroborate salts from aromatic amines, tert-butyl nitrite, and boron trifluoride etherate in anhydrous media
Journal ArticleDOI
Fluorinated benzoic acid derivatives
TL;DR: In this paper, the authors were interested in the preparation of 3,4,5-trifluorophenylalanine, a key intermediate for the inhibition of the enzyme PPHO.