Journal ArticleDOI
Synthesis of bicyclic aza-enones via a lewis acid catalysed Michael-type addition with silyl enol ethers bearing a nitrogen atom.
TLDR
Silyl enol ethers bearing a nitrogen atom protected by an electron-withdrawing group give in high yield a Micheal-type addition with hemiacetal vinylog or a mixture of methyl vinyl ketone and an alcohol in the presence of boron trifluoride etherate as a catalyst as mentioned in this paper.About:
This article is published in Tetrahedron Letters.The article was published on 1993-06-11. It has received 9 citations till now. The article focuses on the topics: Enol ether & Michael reaction.read more
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Patent
Pyrrolo[2,3-D]pyrimidine compounds
TL;DR: A compound of formula (I) wherein R1, R2 and R3 are as defined in the description, and are inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase (3) and as such are useful therapy as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease and Leukemia and
Patent
3-amino-piperidine derivatives and processes for their preparation
TL;DR: In this article, the 3-amino piperadine derivatives, their intermediates and methods of manufacture are described, including methods of making a compound of the formulas (la) and (lb) wherein R, R2, R3, R4, R,4, n, and n are defined.
Journal ArticleDOI
Synthesis of racemic nitramine, isonitramine and sibirine
TL;DR: Condensation of enol ether with methyl vinyl ketone led easily to ketoaldehyde 7 whose cyclisation afforded the azaspiranic enone 8, a key intermediate for the synthesis of the title alkaloids as discussed by the authors.
Patent
3-Amino-piperidine derivatives and methods of manufacture
TL;DR: In this paper, the 3-amino piperidine derivatives, their intermediates and methods of manufacture were described, including methods of making a compound of the formulas (Ia and (Ib) wherein R 1, R 2, R 3, R 4, R 14, and n are defined.
Journal ArticleDOI
Novel approach toward the morphine skeleton. Synthesis of 1-(5-benzyloxy-2-bromo-4-methoxybenzyl)-6-oxo-3,4,6,7,8,8a-hexahydro-1H-isoquinoline-2-carboxylic acid phenyl ester via N-acylpyridinium salt chemistry
TL;DR: A dihydropyridone-mediated approach to the morphine skeleton was investigated in this paper, where the hexahydroisoquinoline 2 was synthesized in nine steps using N-acylpyridinium chemistry and dihydro-synthetic functionalization methods.
References
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Journal ArticleDOI
Chemistry of carbanions. XVIII. Preparation of trimethylsilyl enol ethers
Journal ArticleDOI
A new practical synthesis of silyl enol ethers
TL;DR: In this article, a new route to enoxysilanes is described from simple enolizable aldehydes or ketones, using the trimethylchlorosilane-sodium iodide-tertiary amine reagent in acetonitrile.
Journal ArticleDOI
A new practical synthesis of silyl enol ethers : II. From α,β-unsaturated aldehydes and ketones
TL;DR: In acetonitrile as the solvent and in the presence of a tertiary amine the trimethylchlorosilane/sodium iodide reagent provides the corresponding siloxy dienes when reacted with α,β-unsaturated series as mentioned in this paper.
Journal ArticleDOI
Specific enolates from .alpha.-amino ketones
Journal ArticleDOI
Une méthode simple et efficace de préparation de composés dicarbonylés-1,5
TL;DR: In this paper, a method for 1,5-dicarbonyl compounds from enol ethers, methyl vinyl ketone and boron triflouride etherate was described.