Journal ArticleDOI
Synthesis of Halogen Derivatives of Benzo[h]chromene and Benzo[a]anthracene with Promising Antimicrobial Activities.
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In this paper, the synthesis of novel 7-(4-halophenyl)-8,9-dihydro-7H-12-oxa-9,11-diaza-benzo[a]anthracene derivatives has been reported.Abstract:
The synthesis of novel 7-(4-halophenyl)-8,9-dihydro-7H-12-oxa-9,11-diaza-benzo[a]anthracene derivatives has been reported. The key intermediate 3-amino-9-chloro-1-(4-halophenyl)-1H-benzo[h]chromene-2-carbonitrile (3) was obtained by treating 4-halobenzylidenmalononitriles (1a-c) and ethyl 4-halobenzylidenmalonates (1d-f) with 4-chloro-1-naphthol (2) in ethanolic piperidine solution. Antimicrobial activity was shown for most of the synthesized compounds.read more
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Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana)
Salwa Mansur Ali,Ruqaiyyah Siddiqui,Seng-Kai Ong,Muhammad Raza Shah,Ayaz Anwar,Peter J. Heard,Naveed Ahmed Khan +6 more
TL;DR: In this paper, the authors characterized antibacterial properties in extracts of various body organs of cockroaches (Periplaneta americana) and showed potent antibacterial activity in crude brain extract against methicillin-resistant Staphylococcus aureus and neuropathogenic Escherichia coli K1.
Journal ArticleDOI
Studies on the synthesis, in vitro antitumor activity of 4H-benzo[h]chromene, 7H-benzo[h]chromene[2,3-d]pyrimidine derivatives and structure–activity relationships of the 2-,3- and 2,3-positions
TL;DR: The structure–activity relationship (SAR) study revealed that the antitumor activity on 4H-benzo[h]chromenes with modification at the 2-,3- and 2,3-positions were significantly affected by the lipophilicity (hydrophobic or hydrophilic).
Journal ArticleDOI
Synthesis, antitumor activity, and structure–activity relationship of some 4H-pyrano[3,2-h]quinoline and 7H-pyrimido[4′,5′:6,5]pyrano[3,2-h]quinoline derivatives
TL;DR: In this paper, several 4H-pyrano[3,2-h]quinoline derivatives were obtained by treatment of 8-hydroxyquinoline with α-cyano-p-chloro/bromocinnamonitrile.
Journal ArticleDOI
Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions.
Rawda M. Okasha,Fawzia F. Al-blewi,Tarek H. Afifi,Arshi Naqvi,Ahmed M. Fouda,Al-Anood M. Al-Dies,Ahmed M. El-Agrody +6 more
TL;DR: The structure–activity relationships (SAR) study highlights that the antitumor activity of the target compounds was significantly affected by the lipophilicity of the substituent at 2- or 3- and fused rings at the 2,3-positions.
Journal ArticleDOI
Cytotoxic and apoptotic effects of synthetic benzochromene derivatives on human cancer cell lines.
Asma Kheirollahi,Mahboobeh Pordeli,Maliheh Safavi,Sara Mashkouri,M. Reza Naimi-Jamal,Sussan Kabudanian Ardestani +5 more
TL;DR: The results of apoptosis evaluation suggested that the cytotoxic activity of these compounds in breast cancer cells occurs via apoptosis, and Cytotoxic and apoptotic effects of these drugs indicated that they can be a good candidate for further pharmacological studies to discover effective anticancer agents.
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Journal ArticleDOI
Synthesis of halogen derivatives of benzo[h]chromene and benzo[a]anthracene with promising antimicrobial activities.
TL;DR: The synthesis of novel 7-(4-halophenyl)-8,9-dihydro-7H-12-oxa-9,11-diaza-benzo[a]anthracene derivatives has been reported and antimicrobial activity was shown for most of the synthesized compounds.