The instant invention relates to a compound of formula (I) wherein Ra and P are: (a) hydrogen, (b) methyl, or (c) a hydroxy protecting group and an efficient process for its synthesis.

Synthesis of Potentially Useful Intermediates for 1-Fluorocarbapenems.

Preparation of beta-methyl carbapenem intermediates

Chemistry indexing and abstracting service

The displacement reaction of the 4-acetoxyazetidin-2-one (6) with dimethyl fluoromalonate was readily performed in the presence of lithium hexamethyldisilazide. The product (7), quantitatively obtained, was converted into two potential synthetic intermediates (4) and (5) of 1-fluorocarbapenem derivatives

Synthesis of Potentially Useful Intermediates for 1-Fluorocarbapenems.

Citations

Preparation of beta-methyl carbapenem intermediates

References

Synthesis of potentially useful intermediates for 1-fluorocarbapenems

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