Journal ArticleDOI
Synthesis of thromboxane receptor antagonists with bicyclo[3.1.0]hexane ring systems
Susumu Kamata,Nobuhiro Haga,Tatsuo Tsuri,Kiyohisa Uchida,Hisato Kakushi,Hitoshi Arita,Kohji Hanasaki +6 more
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TLDR
The inhibitory effects of their sodium salts for the platelet aggregation induced by arachidonic acid with rabbit platelet-rich plasma and platelet aggregating induced by collagen with rat washed platelets were examined.Abstract:
Thromboxane A2 receptor antagonists 11a, 15a, 26a, 30a, 34a, 36a, 46a, 52a, 61a, 72a, and 82a, which contain 6-oxabicyclo[3.1.0]hexane, 6-thiabicyclo[3.1.0]hexane, bicyclo[3.1.0]hexane, or 6,6-dimethylbicyclo[3.1.0]hexane ring systems with heptenoic and (phenylsulfonyl)amino side chains, and their corresponding sodium salts and methyl esters were synthesized. This study then examined the inhibitory effects of their sodium salts for the platelet aggregation induced by arachidonic acid with rabbit platelet-rich plasma and platelet aggregation induced by collagen with rat washed platelets.read more
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Reference EntryDOI
The Mitsunobu Reaction
TL;DR: In this paper, the authors present a review of the literature on the MAD/triphenylphosphine redox system, with emphasis on the literature between 1981 and 1988.
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Prostanoid receptor antagonists: development strategies and therapeutic applications
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Hemiaminals as substrates for sulfur ylides: direct asymmetric syntheses of functionalised pyrrolidines and piperidines.
TL;DR: Phenyl stabilised chiral sulfur ylides react with five-membered-ring hemiaminals to give functionalised pyrrolidines directly with high enantioselectivity and can be diverted to give piperidines instead by isolation of the intermediate epoxide and treatment with TMSOTf.
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Aminals as substrates for sulfur ylides: a synthesis of functionalized aziridines and N-heterocycles.
TL;DR: Sulfur ylides stabilized by Ar, vinyl, or amide groups react with five-membered-ring tert-butylsulfinyl aminals to give functionalized chiral, nonracemic aziridines in high yield and with good selectivities.