Journal ArticleDOI
Temporal aspects of the regulation of corpus luteum function by luteinizing hormone, prolactin and placental luteotrophin during the first half of pregnancy in the rat.
Walter K. Morishige,I. Rothchild +1 more
TLDR
Intact rats were injected once, subcutaneously, with either 1.0 mg of ergocornine, free base (ECO), to prevent prolactin release, or an equine antiserum to bovine LH (LH-AS), to neutralize endogenous LH, on one of the days between days 6 and 12 of pregnancy.Abstract:
Intact rats were injected once, subcutaneously, with either 1.0 mg of ergocornine, free base (ECO), to prevent prolactin release, or an equine antiserum to bovine LH (LH-AS), to neutralize endogenous LH, on one of the days between days 6 and 12 of pregnancy. ECO treatment was uniformly abortifacient on day 6, only slightly less so on day 7, and was ineffective at 0400 hr or later on day 8. LH-AS treatment on day 6 or 7 induced abortion in very few rats; at 0400 hr on day 8, it induced abortion in 92%, and at 1200 or 1600 hr on day 8 or at 1200 hr on day 10, in 100% of the rats; when given on day 12, it was again ineffective. ECO did not depress serum LH or FSH levels, but abolished the nocturnal surge of prolactin; ECOinduced abortions could be prevented by treatment with prolactin but not with LH. Absorption of the LH-AS with LH, but not with either FSH or bovine serum abolished its abortifacient effect. A severe fall in the serum progesterone level occurred within 12 to 48 hr after treatment with either...read more
Citations
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Journal ArticleDOI
Prolactin: Structure, Function, and Regulation of Secretion
TL;DR: The purpose of this review is to provide a comprehensive survey of the current understanding of prolactin's function and its regulation and to expose some of the controversies still existing.
Journal ArticleDOI
Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin
TL;DR: Elevated or recently elevated levels of estrogen may be necessary for the induction of full maternal behavior by oxytocin, functions related to parturition and nuturing in virgin female rats.
Journal ArticleDOI
The Molecular Control of Corpus Luteum Formation, Function, and Regression
TL;DR: The generation of transgenic, knockout and knockin mice and the development of innovative technologies have revealed a novel role of several molecules in the reprogramming of granulosa cells into luteal cells and in the hormonal and molecular control of the function and demise of the CL.
Book ChapterDOI
The Regulation of the Mammalian Corpus Luteum
TL;DR: This chapter presents an overview of the regulation of the mammalian corpus luteum (CL), an ovarian follicle in which the rapid regression is temporarily arrested and progesterone secretion goes hand in hand with the postponement of regression.
Journal ArticleDOI
Medial preoptic area and onset of maternal behavior in the rat.
TL;DR: It was concluded that the medial preoptic area (MPOA) is involved not only in the maintenance of maternal behavior but in the hormonally mediated onset of mothers behavior and the onset of maternalbehavior induced in virgin females by pup stimulation.