Journal ArticleDOI
Temporal Patterns of Stroke Onset The Framingham Study
Margaret Kelly-Hayes,Philip A. Wolf,Carlos S. Kase,Frederick N. Brand,Jacqueline M. McGuirk,Ralph B. D'Agostino +5 more
TLDR
Temporal patterns of stroke onset were observed for season, day of the week, time of day, and place in a community-based population, suggesting that there are periods of increased risk of stroke that may be amenable to preventive strategies.Abstract:
Background and Purpose Several studies have shown stroke onset to vary by season, day of the week, and time of day. These temporal patterns, which may provide insights into pathogenesis, were found mainly in clinical series, which can be subject to selection bias. To obtain a less distorted picture of stroke onset, we examined the month and season, day of the week, time, and place stroke occurred in a community-based cohort. Methods Over a 40-year period of surveillance of the Framingham Study cohort of 5070 people aged 30 to 62 years and free of stroke and cardiovascular disease at entry, 637 completed initial strokes occurred. Month, season, day of the week, time of day, and place of occurrence of stroke were ascertained systematically and related prospectively to stroke incidence, subtype, and gender. Results Winter was the peak season for cerebral embolic strokes. Significantly more stroke events occurred on Mondays than any other day, particularly for working men. For intracerebral hemorrhages, a thi...read more
Citations
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Journal ArticleDOI
Circadian Variation in the Timing of Stroke Onset A Meta-analysis
TL;DR: These data support the presence of a circadian pattern in the onset of stroke, with a significantly higher risk in the morning.
Journal ArticleDOI
Inflammation and Infections as Risk Factors for Ischemic Stroke
TL;DR: Clinical data on infection and inflammation as risk or trigger factors for human stroke are summarized and current evidence for the hypothesis of a functional interrelation between traditional risk factors, genetic predisposition, and infection/inflammation in stroke pathogenesis is investigated.
Journal ArticleDOI
Triggering of Acute Cardiovascular Disease and Potential Preventive Strategies
TL;DR: The aim of the present review is to update current knowledge about triggering of acute cardiovascular disease (CVD), place it in the context of advances in understanding of the mechanisms of onset, and suggest a 5-faceted strategy to protect against the pathophysiological effects of triggering.
Journal ArticleDOI
Increased winter mortality from acute myocardial infarction and stroke: the effect of age
TL;DR: The elderly demonstrate a greater winter increase in AMI and stroke mortality than younger individuals, and an understanding of these seasonal patterns may provide novel avenues for research in cardiovascular disease prevention.
Journal ArticleDOI
Temporal distribution of partial seizures: comparison of an animal model with human partial epilepsy.
TL;DR: In this article, the authors compared daily times of partial seizures determined by continuous electroencephalography among patients with mesial temporal lobe epilepsy (MTLE; n = 64), those with extratemporal lobe (XTLE, n = 26) or lesional temporal lobe Epilepticus (LTLE), n = 8, and a rat model similar to MTLE in which rats become epileptic after electrically induced limbic status epilepticus, and concluded that limbic seizure occurrence has a relation to the circadian regulatory system.
References
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John R. Marler,Thomas R. Price,G L Clark,James E. Muller,Thomas L. Robertson,Jay P. Mohr,Daniel B. Hier,Philip A. Wolf,Louis R. Caplan,Mary A. Foulkes +9 more
TL;DR: The time of onset of ischemic stroke was determined for 1,167 of 1,273 patients during the collection of data by four academic hospital centers between June 30, 1983, andJune 30, 1986.
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Cigarette smoking and alcohol consumption as risk factors for aneurysmal subarachnoid hemorrhage.
TL;DR: Higher levels of erythrocyte mean corpuscular volume in patients with subarachnoid hemorrhage than in control subjects supported the notion of different smoking and drinking habits.
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Weekly variation of acute myocardial infarction. Increased Monday risk in the working population.
TL;DR: The onset of acute myocardial infarction demonstrates a peak on Monday primarily in the working population, and if this finding is confirmed in other communities, it may aid in identifying acute triggering events of myocardia infarctions and perhaps in improving prevention of the disease.
Journal ArticleDOI
Cigarette smoking, alcohol use, and subarachnoid hemorrhage.
TL;DR: Cigarette smoking and heavy alcohol use are associated with the occurrence of subarachnoid hemorrhage and were not substantially altered after adjusting for several possible confounding factors, including a history of hypertension.