Temporary Occlusion of the Middle Cerebral Artery in the Monkey: Clinical and Pathological Observations
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The results suggest that reestablishment of flow by surgical means within a few hours after MCA occlusion in selected patients might result in significant restoration of neurological function.Abstract:
The right middle cerebral artery (MCA) was exposed in monkeys via a retro-orbital microsurgical approach. In 43 animals a temporary occlusive clip was placed on the MCA origin for one to 24 hours. In 20 animals, the origin of the MCA was permanently occluded. Clinical evaluation of the monkeys one to three days postoperatively showed that one to two-hour clipping caused no or mild neurological deficits, four-hour clipping caused mild to moderate deficits, six to eight-hour clipping caused moderate to severe deficits, and 24-hour clipping produced severe deficits or death, a result equivalent to that produced by permanent occlusion. Gross and microscopical evaluation of the brains showed that one to two-hour clipping usually caused no or mild damage, four-hour clipping caused mild to moderate damage (often with capsular sparing), and six to eight-hour clipping and 24-hour clipping produced severe extensive infarction not different from that caused by permanent occlusion. Six to eight-hour clipping and 24-h...read more
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References
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Intracranial hemorrhage following surgical revascularization for treatment of acute strokes.
TL;DR: The category of patients for whom revascularization seems most helpful is represented by those individuals whose totally or partially occlusive lesions produce transient ischemic attacks or chronic lowgrade insufficiency in the apparent absence of cerebral infarction.
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Cerebral circulation and metabolism during thiopental anesthesia and hyperventilation in man
Journal ArticleDOI
Restoration of Middle Cerebral Artery Flow in Experimental Infarction
Journal ArticleDOI
Regional cerebral blood flow in apoplexy due to occlusion of the middle cerebral artery.
TL;DR: A group of apoplectics with a single pathogenesis, i.l.e., with acute occlusion of the middle cerebral artery, has been studied with the aim of collecting information on the regional cerebral blood flow (rCBF) and its regulation in a well-defined type of Apoplexy.
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