The absorption, excretion, and distribution of penicillin
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This article is published in Journal of Clinical Investigation.The article was published on 1943-05-01 and is currently open access. It has received 150 citations till now. The article focuses on the topics: Penicillin & Excretion.read more
Citations
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Beta-lactam Antibiotics: From Antibiosis to Resistance and Bacteriology
TL;DR: A review focusing on the era of antibiosis that led to a better understanding of bacterial morphology, in particular the cell wall component peptidoglycan, is presented in this paper.
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The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective
Sanjay K. Nigam,Kevin T. Bush,Gleb Martovetsky,Sun-Young Ahn,Henry C. Liu,Erin Richard,Vibha Bhatnagar,Wei Wu +7 more
TL;DR: According to the "Remote Sensing and Signaling Hypothesis," which is elaborated in detail here, Oats may function in remote interorgan communication by regulating levels of signaling molecules and key metabolites in tissues and body fluids.
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Penicillin in the treatment of infections: a report of 500 cases
TL;DR: The purpose in this report is to acquaint the medical profession with the results that have been obtained in the treatment of 500 cases of various infections with penicillin.
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Penicillin as a chemotherapeutic agent
TL;DR: In 1929, while examining plates seeded with staphylococci, Fleming observed that colonies failed to grow in the neighborhood of a colony of a contaminating mold.
Journal ArticleDOI
Variation in antibiotic-induced microbial recolonization impacts on the host metabolic phenotypes of rats.
Jonathan R. Swann,Jonathan R. Swann,Kieran Tuohy,Peter Lindfors,Duncan T. Brown,Glenn R. Gibson,Ian D. Wilson,James E. Sidaway,Jeremy K. Nicholson,Elaine Holmes +9 more
TL;DR: Antibiotic treatment induced a profound effect on the microbiome structure, which was reflected in the metabotype, and the recolonization process was sensitive to the microenvironment, which may impact on understanding downstream consequences of antibiotic consumption in human populations.
References
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Journal Article
On the Antibacterial Action of Cultures of a Penicillium, with Special Reference to their Use in the Isolation of B. influenzæ
TL;DR: It is suggested that it may be an efficient antiseptic for application to, or injection into, areas infected with penicillin-sensitive microbes, and its value as an aid to the isolation of B. influenzae has been demonstrated.
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An Enzyme from Bacteria able to Destroy Penicillin
Edward P. Abraham,E. Chain +1 more
TL;DR: It is confirmed that the growth of B. coli and a number of other bacteria belonging to the colityphoid group was not inhibited by penicillin, and the cause of the resistance of these organisms to the action of Penicillin is found.
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Further observations on penicillin
Edward P. Abraham,E. Chain,C.M. Fletcher,A. D. Gardner,N. G. Heatley,M. A. Jennings,Howard Florey +6 more
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Penicillin as a chemotherapeutic agent
E. Chain,Howard Florey,A. D. Gardner,N. G. Heatley,M. A. Jennings,J. Orr-Ewing,A. G. Sanders +6 more
Journal ArticleDOI
A Method for Determining the Concentration of Penicillin in Body Fluids and Exudates
TL;DR: It is possible to determine 0.0039 Florey unit per 0.2 cc of solution by this method to determine the concentration of penicillin in various body fluids and exudates.