Journal ArticleDOI
The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults.
William A. Knaus,Douglas P. Wagner,Elizabeth A. Draper,Jack E. Zimmerman,Marilyn Bergner,Paulo G. Bastos,Carl A. Sirio,Donaldj Murphy,Ted Lotring,Anne M. Damiano +9 more
TLDR
The overall predictive accuracy of the first-day APACHE III equation was such that, within 24 h ofICU admission, 95 percent of ICU admissions could be given a risk estimate for hospital death that was within 3 percent of that actually observed.About:
This article is published in Chest.The article was published on 1991-12-01. It has received 3693 citations till now. The article focuses on the topics: SAPS II & Intensive care.read more
Citations
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Journal ArticleDOI
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
Roger C. Bone,Robert A. Balk,F. B. Cerra,R. P. Dellinger,A. M. Fein,William A. Knaus,Roland M. H. Schein,W. J. Sibbald +7 more
TL;DR: An American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference was held in Northbrook in August 1991 with the goal of agreeing on a set of definitions that could be applied to patients with sepsis and its sequelae as mentioned in this paper.
Journal ArticleDOI
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.
Roy G. Brower,Michael A. Matthay,Alan H. Morris,David A. Schoenfeld,B. Taylor Thompson,Arthur P. Wheeler +5 more
TL;DR: In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.
Journal ArticleDOI
The American-European Consensus Conference on ARDS: Definitions, mechanisms, relevant outcomes, and clinical trial coordination
Gordon R. Bernard,Antonio Artigas,Kenneth L. Brigham,J. Carlet,K. Falke,L. Hudson,M. Lamy,J. R. LeGall,Alan H. Morris,Roger G. Spragg +9 more
TL;DR: The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality, and financial cost.
Journal ArticleDOI
A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study
TL;DR: The SAPS II, based on a large international sample of patients, provides an estimate of the risk of death without having to specify a primary diagnosis, and is a starting point for future evaluation of the efficiency of intensive care units.
Journal ArticleDOI
A controlled trial to improve care for seriously ill hospitalized patients: The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT)
Alfred F. Connors,Neal V. Dawson,N. A. Desbiens,William J. Fulkerson,Lee Goldman,William A. Knaus,Joanne Lynn,R. K. Oye,M. Bergner,Ann M. Damiano,R. Hakim,D. J. Murphy,J. Teno,B. Virnig,Douglas P. Wagner,A. W. Wu,Y. Yasui,D. K. Robinson,B. Kreling +18 more
TL;DR: A 2-year prospective observational study (phase I) with 4301 patients followed by a two-year controlled clinical trial (phase II) with 4804 patients and their physicians randomized by specialty group to the intervention group or control group (n=2652).
References
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Journal ArticleDOI
APACHE II: a severity of disease classification system.
TL;DR: The form and validation results of APACHE II, a severity of disease classification system that uses a point score based upon initial values of 12 routine physiologic measurements, age, and previous health status, are presented.
Journal ArticleDOI
APACHE II--a severity of disease classification system.
Journal ArticleDOI
Flexible regression models with cubic splines
TL;DR: In this article, the authors describe the use of cubic splines in regression models to represent the relationship between the response variable and a vector of covariates, which can help prevent the problems that result from inappropriate linearity assumptions.
Journal ArticleDOI
Clinical versus actuarial judgment
TL;DR: Research comparing these two approaches to decision-making shows the actuarial method to be superior, factors underlying the greater accuracy of actuarial methods, sources of resistance to the scientific findings, and the benefits of increased reliance on actuarial approaches are discussed.
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Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group.
Elizabeth J. Ziegler,Charles J. Fisher,Charles L. Sprung,Richard C. Straube,Jerald C. Sadoff,Garrett E. Foulke,CH Wortel,Fink Mp,Dellinger Rp,Nelson N.H. Teng +9 more
TL;DR: A randomized, double-blind trial in patients with sepsis and a presumed diagnosis of gram-negative infection was conducted in this article, where the patients received either a single 100mg intravenous dose of HA-1A or placebo.