Journal ArticleDOI
The Contraceptive Vaginal Ring
Jill Edwardson,Roxanne Jamshidi +1 more
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The contraceptive vaginal ring offers effective contraception that is self-administered, requires less frequent dosing than many other forms of contraception, and provides low doses of hormones.Abstract:
The contraceptive vaginal ring offers effective contraception that is self-administered, requires less frequent dosing than many other forms of contraception, and provides low doses of hormones. NuvaRing (Organon, Oss, The Netherlands), the only contraceptive vaginal ring approved for use in the United States, contains etonogestrel and ethinyl estradiol. It is inserted into the vagina for 3 weeks, followed by a 1-week ring-free period, and works by inhibiting ovulation. Most women note a beneficial effect on bleeding profiles and are satisfied with NuvaRing. Commonly reported adverse events include vaginitis, leukorrhea, headaches, and device-related events such as discomfort. Serious adverse events are rare. In Chile and Peru, progesterone-only vaginal contraceptive rings are available for nursing women. Studies are ongoing examining new formulations of vaginal contraceptive rings.read more
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Journal ArticleDOI
Contraception for adolescents.
Mary A. Ott,Gina S. Sucato +1 more
TL;DR: This technical report provides an evidence base for the accompanying policy statement and addresses key aspects of adolescent contraceptive use, including the following: sexual history taking, confidentiality, and counseling; adolescent data on the use and side effects of newer contraceptive methods; new data on older contraceptives methods; and evidence supporting the use of contraceptives in adolescent patients with complex medical conditions.
Journal ArticleDOI
Review of the combined contraceptive vaginal ring, NuvaRing.
TL;DR: Good results with respect to contraceptive efficacy, cycle control, tolerability, and acceptability as achieved with NuvaRing in the large non-comparative registration studies were confirmed in the RCTs comparing Nuva ring with different COCs.
Journal ArticleDOI
Pharmacokinetics of a Multipurpose Pod-Intravaginal Ring Simultaneously Delivering Five Drugs in an Ovine Model
John A. Moss,Amanda M. Malone,Thomas J. Smith,Sean Kennedy,Cali Nguyen,Kathleen L. Vincent,Massoud Motamedi,Marc M. Baum +7 more
TL;DR: This proof-of-principle study demonstrates that pod IVRs can deliver three ARVs from different mechanistic classes and a progestin-estrogen combination over the wide range needed for putative preventative efficacy.
Journal ArticleDOI
Novel multipurpose pod-intravaginal ring for the prevention of HIV, HSV, and unintended pregnancy: Pharmacokinetic evaluation in a macaque model
James M. Smith,John A. Moss,Priya Srinivasan,Irina Butkyavichene,Manjula Gunawardana,Rob Fanter,Christine S. Miller,Debbie Sanchez,Flora Yang,Shanon Ellis,Jining Zhang,Mark A. Marzinke,Craig W. Hendrix,Amita Kapoor,Marc M. Baum +14 more
TL;DR: This proof of principle study demonstrates that MPT-pod IVRs could serve as a potent biomedical prevention tool to protect women’s sexual and reproductive health and may increase adherence to HIV PrEP even among younger high-risk populations.
Journal ArticleDOI
Managing women with gestational diabetes mellitus in the postnatal period
TL;DR: Current recommendations for managing women with GDM in the postnatal period are discussed, with particular attention to postpartum diabetes screening, prevention of future glucose intolerance and family planning.