Journal ArticleDOI
The cytotoxicity of bupivacaine, ropivacaine, and mepivacaine on human chondrocytes and cartilage.
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TLDR
Bupivacaine, ropivacane, and mepvacaine are chondrotoxic in a time-dependent, concentration- dependent, and drug-dependent manner, and analgesic potencies do not directly correlate.Abstract:
BACKGROUND:Intraarticular injections of local anesthetics are frequently used as part of multimodal pain regimens. However, recent data suggest that local anesthetics affect chondrocyte viability. In this study, we assessed the chondrotoxic effects of mepivacaine, ropivacaine, and bupivacaine. We hyread more
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Single-dose local anesthetics exhibit a type-, dose-, and time-dependent chondrotoxic effect on chondrocytes and cartilage: a systematic review of the current literature
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The Science of Local Anesthesia: Basic Research, Clinical Application, and Future Directions.
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References
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Journal ArticleDOI
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TL;DR: It is demonstrated that mechanical injury induces chondrocyte apoptosis and release of GAG from the matrix and suggests that a therapeutic window may exist where apoptosis could be inhibited.
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