Journal ArticleDOI
The Determination of Plasma Nitrite and Nitrate by Capillary Ion Analysis
A.M. Leone,S. Moncada +1 more
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In this paper, a simple capillary electrophoresis method which requires very little sample handling and can measure both nitrite and nitrate in a single short run time is presented.About:
This article is published in Methods.The article was published on 1995-02-01. It has received 59 citations till now. The article focuses on the topics: Nitrite & Nitrate.read more
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Journal ArticleDOI
Genome of the Extremely Radiation-Resistant Bacterium Deinococcus radiodurans Viewed from the Perspective of Comparative Genomics
Kira S. Makarova,Kira S. Makarova,L. Aravind,Yuri I. Wolf,Roman L. Tatusov,Kenneth W. Minton,Eugene V. Koonin,Michael J. Daly +7 more
TL;DR: An extensive comparative sequence analysis of the Deinococcus genome suggests that several different biological mechanisms contribute to the multiple DNA repair-dependent phenotypes of this organism.
Journal ArticleDOI
Specific Interaction of DNA Polymerase β and DNA Ligase I in a Multiprotein Base Excision Repair Complex from Bovine Testis
Rajendra Prasad,Rakesh K. Singhal,Deepak Srivastava,James T. Molina,Alan E. Tomkinson,Samuel H. Wilson +5 more
TL;DR: β-pol and DNA ligase I are components of a multiprotein complex that performs BER, and it is concluded that β-Pol and DNAligase I were co-immunoprecipitated from the testis nuclear extract with anti β-pol IgG.
Journal ArticleDOI
FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.
TL;DR: It is demonstrated by immunodepletion experiments that 5′-dRP-N3excision in long patch BER of uracil-DNA in a human lymphoid cell extract is, indeed, dependent upon FEN1 and that human F EN1 and β-pol can cooperate in longPatch BER excision and specify the predominant excision product seen with a cell extract.
Journal ArticleDOI
DNA Polymerase β-mediated Long Patch Base Excision Repair POLY(ADP-RIBOSE) POLYMERASE-1 STIMULATES STRAND DISPLACEMENT DNA SYNTHESIS
Rajendra Prasad,Olga I. Lavrik,Soon-Jong Kim,Padmini S. Kedar,Xiao-Ping Yang,Brian Vande Berg,Samuel H. Wilson +6 more
TL;DR: The DNA synthesis and flap excision steps in long patch BER are examined using a reconstituted system containing a 34-base pair BER substrate and five purified human enzymes: uracil-DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta, flap end onuclease-1 (FEN-1), and PARP-1.
Journal ArticleDOI
Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism.
TL;DR: The full-length enzyme and the 8-kDa domain efficiently remove the 5' dRP from a preincised AP site in the absence of Mg2+, and the pH profiles of beta-pol and 8- kDa domain dRP lyase catalytic efficiency exhibit a broad alkaline pH optimum.
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Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair
Yoshihiro Matsumoto,Kyung Kim +1 more