Journal ArticleDOI
The Evaluation and Management of Adult Intracerebral Hemorrhage.
Xuemei Cai,Jonathan Rosand +1 more
TLDR
The authors outline the most up-to-date knowledge, including the results of the latest phase III clinical trials on the specialized care needed to treat patients with ICH, and provide an overview on how to achieve rapid diagnosis and the initial steps of intervention to reduce hematoma volume or prevent expansion.Abstract:
Intracerebral hemorrhage (ICH) is the most disabling and deadly form of stroke. Although mortality remains high, new data suggest that outcomes can be improved with standardized medical care. In this review, the authors outline the most up-to-date knowledge, including the results of the latest phase III clinical trials on the specialized care needed to treat patients with ICH. They provide an overview on how to achieve rapid diagnosis and the initial steps of intervention to reduce hematoma volume or prevent expansion by modifying potentially treatable conditions, such as underlying vascular etiologies, blood pressure control, and coagulopathies. Grading scales can help identify patients at risk for hematoma expansion and functional disabilities and guide clinical decision making. Other medical management topics important to recovery and prevention of secondary brain injury include seizure prevention and treatment, glycemic control, temperature control, and deep venous thrombosis prophylaxis and treatment. Treatment options in surgery are also possible in select patients; there are emerging studies regarding minimally invasive surgery for the management of ICH. These aggressive therapies are essential to lower the morbidity and mortality of patients presenting with ICH.read more
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Journal ArticleDOI
Current management of spontaneous intracerebral haemorrhage
Cyrus K. Dastur,Wengui Yu +1 more
TL;DR: It is important to start intermittent pneumatic compression devices at the time of admission and subcutaneous unfractionated heparin in stable patients within 48 hours of admission for prophylaxis of venous thromboembolism.
Journal ArticleDOI
Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis
TL;DR: Hcy level may be an aggravating factor in atherosclerosis, which is positively associated with high risk of ICH, and race-specific differences between Asians and Caucasians have no impact on the risk ofICH.
Journal ArticleDOI
Today's Approach to Treating Brain Swelling in the Neuro Intensive Care Unit.
TL;DR: The authors outline the current approach for rapid diagnosis and intervention to reduce mortality and morbidity associated with brain swelling.
Journal ArticleDOI
Hemoglobin enhances miRNA-144 expression and autophagic activation mediated inflammation of microglia via mTOR pathway.
TL;DR: The results suggested that miRNA-144 contributed to hemoglobin mediated autophagic activation and inflammation of microglia via mTOR pathway and miRNA based treatment provided novel therapeutical strategy for intracerebral hemorrhage.
Journal ArticleDOI
Возможности использования шкал клинико-нейровизуализационной оценки степени тяжести пациентов в дебюте мозгового геморрагического супратентриального инсульта для прогнозирования исхода острого периода заболевания
TL;DR: This study included clinical assessment using National Institute of Health Stroke Scale and Glasgow Coma Scale, visualization of cerebral structures and integrated assessment of health state severity using the Hemphill-ICH Scale and ICH-GS.