Journal ArticleDOI
The fate of 3h-iso-proterenol in the rat.
TLDR
The delay of the urinary excretion of radioactivity following an injection of 3H-norepinephrine is caused by its binding in the tissues and slow release, and only negligible quantities of3H-iso-proterenol were found bound in tissues under similar conditions.About:
This article is published in Biochemical Pharmacology.The article was published on 1964-08-01. It has received 156 citations till now. The article focuses on the topics: Excretion & Urine.read more
Citations
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Journal ArticleDOI
The pineal gland: a neurochemical transducer.
TL;DR: In this article, Axelrod applied signal transduction theory to his research on the metabolic function of serotonin, even describing the pineal gland as a "neurochemical transducer."
Journal ArticleDOI
The pharmacological differentiation of adrenergic receptors
TL;DR: The Ahlquist classification has been applied with greatest success to adrenergic receptors of various smooth muscles and heart and met the challenge that a third type of adrenergic receptor was responsible for mediating inhibition of intestinal smooth muscle.
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The inhibition of noradrenaline uptake by sympathomimetic amines in the rat isolated heart.
A. S. V. Burgen,L. L. Iversen +1 more
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Evidence for reduction of norepinephrine uptake sites in the failing human heart
TL;DR: In human heart failure, there is a presynaptic defect in the sympathetic nervous system, leading to reduced uptake-1 activity, which can be mimicked by the effects of uptake blocking agents, such as cocaine and desipramine, in the nonfailing heart only.
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Evaluation of the cardiac effects of several beta adrenergic blocking agents
TL;DR: As an experimental tool, a cardiac adrenergic blocking agent is clearly more useful the greater the range of concentrations over which it exerts its blocking action without producing other effects.
References
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Journal ArticleDOI
Enzymatic O-methylation of epinephrine and other catechols.
Julius Axelrod,Robert Tomchick +1 more
TL;DR: The properties of an enzyme that transfers the methyl group of S-adenosylmethionine to the hydroxyl group in position 3 of epinephrine and other catechols are described.
Journal ArticleDOI
Effect of cocaine on the disposition of noradrenaline labelled with tritium.
TL;DR: COCAINE potentiates the responses of sympathetically innervated organs to adrenaline, noradrenaline and sympathetic nerve stimulation, and several explanations have been offered for this.
Journal ArticleDOI
Lack of uptake of catecholamines after chronic denervation of sympathetic nerves.
TL;DR: To clarify phenomena further, the uptake of injected DL β-3H-noradrenaline andDL β- 3H-adrenalin by intact and denervated tissue was compared.
Related Papers (5)
The uptake of catechol amines at high perfusion concentrations in the rat isolated heart: a novel catechol amine uptake process
The inhibition of noradrenaline uptake by sympathomimetic amines in the rat isolated heart.
A. S. V. Burgen,L. L. Iversen +1 more