The genus Vitex: A review.
Anita Rani,Anupam Sharma +1 more
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TLDR
The future scope of Vitex species has been emphasized with a view to establish their multifarious biological activities and mode of action.Abstract:
The review includes 161 references on the genus Vitex, and comprises ethnopharmacology, morphology and microscopy, phytoconstituents, pharmacological reports, clinical studies, and toxicology of the prominent species of Vitex. Essential oils, flavonoids, iridoid glycosides, diterpenoides and ligans constitute major classes of phytoconstituents of the genus. A few species of this genus have medicinal value, among these, leaves and fruits of V. agnus-castus Linn. (Verbenaceae) has been traditionally used in treatment of women complaints. V. agnus-castus has also been included in herbal remedies, which are in clinical use to regulate the menstrual cycle, reduce premenstrual symptom tension and anxiety, treat some menopausal symptoms as well as to treat hormonally induced acne. Despite a long tradition of use of some species, the genus has not been explored properly. In the concluding part, the future scope of Vitex species has been emphasized with a view to establish their multifarious biological activities and mode of action.read more
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Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions.
Muhammad Ali,Tariq Khan,Tariq Khan,Kaneez Fatima,Qurat ul Ain Ali,Muhammad Ovais,Ali Talha Khalil,Ikram Ullah,Abida Raza,Zabta Khan Shinwari,Muhammad Idrees,Muhammad Idrees +11 more
TL;DR: The present review focuses on the composition, pharmacology, and results of experimental trials of selected medicinal plants, finding that further research is needed to identify, characterize, and standardize the active ingredients, useful compounds, and their preparations for the treatment of liver diseases.
Journal ArticleDOI
Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature
Chakrabhavi Dhananjaya Mohan,Shobith Rangappa,Habbanakuppe D. Preetham,S. Chandra Nayaka,Vijai Kumar Gupta,Salundi Basappa,Gautam Sethi,Kanchugarakoppal S. Rangappa +7 more
TL;DR: This review has provided a comprehensive overview of mechanisms of STAT3 signal transduction and its endogenous negative modulators, the role ofSTAT3 in oncogenesis, the interplay of miRNAs in STAT3 signaling, and mechanisms involved in persistent activation of stat3.
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Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties.
TL;DR: This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species, with several molecular mechanisms identified.
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Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia.
Man-Man Li,Xiao-Qin Su,Jing Sun,Yu-Fan Gu,Zheng Huang,Ke-Wu Zeng,Qian Zhang,Yun-Fang Zhao,Daneel Ferreira,Jordan K. Zjawiony,Jun Li,Pengfei Tu +11 more
TL;DR: Six new polyoxygenated triterpenoids, cannabifolins A-F (1-6), and eight known triter penoids, 7-14, were isolated from the leaves of Vitex negundo var.
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Enhanced production of the pharmaceutically important polyphenolic compounds in Vitex agnus castus L. shoot cultures by precursor feeding strategy
TL;DR: The results indicate that V. agnus castus agitated shoot cultures might be considered as a potential biotechnological source of some pharmaceutically important compounds, especially casticin, rutin, neochlorogenic and p‐coumaric acids.
References
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Chaste tree (Vitex agnus-castus) – Pharmacology and clinical indications
TL;DR: It is concluded that dopaminergic compounds present in Vitex agnus castus are clinically the important compounds which improve pre menstrual mastodynia and possibly also other symptoms of the premenstrual syndrome.
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Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L.
TL;DR: Two pentacyclic triterpenoids, betulinic acid and ursolic acid, were isolated for the first time from leaves of Vitex negundo L. along with three other compounds; an aliphatic alcohol n‐hentriacontanol (1), β‐sitosterol (2) and p‐hydroxybenzoic acid (5) and have shown a little antifeedant activity against the larvae and did not show any antibacterial activity.
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Vitex agnus castus: a systematic review of adverse events.
TL;DR: Although further rigorous studies are needed to assess the safety of VAC, the data available seem to indicate that VAC is a safe herbal medicine.
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Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells.
TL;DR: Six flavonoids, persicogenin (1), artemetin (2), luteolin (3), penduletin (4), vitexicarpin (5) and chrysosplenol-D (6), have been isolated for the first time as new cell cycle inhibitors from Vitex trifolia L., a Chinese folk medicine used to treat cancers, through a bioassay-guided separation procedure.
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Phytochemical Analysis and Antioxidant Property of Leaf Extracts of Vitex doniana and Mucuna pruriens.
K. N. Agbafor,N. Nwachukwu +1 more
TL;DR: Results are an indication of antioxidant potential of the extracts and may be responsible for some of the therapeutic uses of these plants.