Journal ArticleDOI
The histopathologic spectrum of erythema induratum of Bazin.
Johann W. Schneider,H F Jordaan +1 more
TLDR
The presence of primary vasculitis and granulomas suggests that types III and IV hypersensitivity reactions play a role in the pathogenesis or erythema induratum of Bazin.Abstract:
Erythema induratum of Bazin is a tuberculid that is strongly associated with tuberculosis. Clinically, erythema induratum of Bazin show recurrent tender subcutaneous nodules that occur mainly on the calves of women with tuberculin hypersensitivity. Previous studies have not documented the histopathologic spectrum of erythema induratum of Bazin in detail. We identified two major histopathologic groups in 19 of 20 skin biopsies obtained from 20 patients with well-documented erythema induratum of Bazin. Six cases (group I) showed focal septolobular panniculitis in close association with a single muscular artery or small vessel with primary neutrophilic vasculitis. Thirteen cases (group II) revealed diffuse septolobular panniculitis with primary neutrophilic vasculitis of either large or smaller vessels. Both groups showed varying combinations and degrees of acute and chronic inflammation, coagulative and caseation-like necrosis, and granulomatous inflammation. Poorly developed granulomas predominated, but mixed, palisading, and lipophagic granulomas also occurred. Inflammation and necrosis were more extensive in group II. Erythema induratum of Bazin may show predominantly acute suppurative or granulomatous panniculitis. Immunostaining showed S100+ antigen-presenting cells, macrophages, and T-lymphocytes. B-lymphocytes were rare. The presence of primary vasculitis and granulomas suggests that types III and IV hypersensitivity reactions play a role in the pathogenesis or erythema induratum of Bazin. The latter remains a clinicopathologic diagnosis, but awareness of the heterogeneous histopathologic spectrum of EIB will ensure a timely diagnosis and institution of antituberculous treatment.read more
Citations
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Journal ArticleDOI
Panniculitis. Part II. Mostly lobular panniculitis.
TL;DR: Participants in this learning activity should be familiar with the pathogenesis, clinical manifestations, histopathologic findings, and treatment options for the most frequent variants of the lobular panniculitis.
Journal ArticleDOI
Cutaneous vasculitis update: neutrophilic muscular vessel and eosinophilic, granulomatous, and lymphocytic vasculitis syndromes.
J. Andrew Carlson,Ko-Ron Chen +1 more
TL;DR: Skin biopsy extending into the subcutis, identifying the dominant inflammatory cell and caliber of vessels affected, extravascular histologic clues such as presence of lichenoid dermatitis or panniculitis, and correlation with clinical data allows for accurate diagnosis of these uncommon vasculitic entities.
Journal ArticleDOI
Erythema nodosum and erythema induratum (nodular vasculitis): diagnosis and management
TL;DR: Erythema nodosum is the most common type of panniculitis; it may be due to a variety of underlying infectious or otherwise antigenic stimuli, but may be associated with several other underlying disorders.
Journal ArticleDOI
Vasculitis in erythema induratum of Bazin: a histopathologic study of 101 biopsy specimens from 86 patients.
TL;DR: Whether or not vasculitis was present in a large series of cases of erythema induratum of Bazin and, when vasculopathy was found, to determine the nature and localization of the involved vessels was investigated.
Journal ArticleDOI
Erythema Induratum of Bazin
José M. Mascaró,Eulalia Baselga +1 more
TL;DR: The etiopathogenesis of erythema induratum of Bazin and its relation to tuberculosis are still controversial, because mycobacteria cannot be cultured from the skin lesions.
References
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Journal ArticleDOI
T Cell Response to Mycobacterium tuberculosis
TL;DR: The development of ideas that the secreted or export proteins of M. tuberculosis are the key protective antigens leading to the initial expression of acquired specific resistance to this organism are reviewed, both from clinical experience and from basic research in animal models.
Journal ArticleDOI
Cutaneous periarteritis nodosa.
TL;DR: In 23 cases, biopsy specimens showed acute inflammatory periarteritis, and noteworthy findings were the absence of systemic disease and the chronic relapsing course.
Journal ArticleDOI
Nodular vascular diseases of the legs: erythema induratum and allied conditions
TL;DR: Interest in a group of diseases which involve primarily the legs, characterized by the presence of nodules and sometimes by ulceration and which are associated with varying degrees of involvement of the blood vessels and fibrosis was aroused.
Journal ArticleDOI
Erythema induratum of Bazin.
Monique Lebel,Michel Lassonde +1 more
TL;DR: This report documents the cases of two patients with ulcerating leg nodules whose clinical and pathologic findings were consistent with the diagnostic criteria for erythema induratum and in whom there was a recent or remote history of tuberculosis.
Journal ArticleDOI
Erythema induratum of Bazin. A clinicopathological study of 20 cases and detection of Mycobacterium tuberculosis DNA in skin lesions by polymerase chain reaction
TL;DR: Results provide direct evidence that mycobacterial components are present in EIB lesions and strongly suggest that M. tuberculosis is involved in the pathogenesis of EIB.