Journal ArticleDOI
The investigation of linkage between a quantitative trait and a marker locus
J. K. Haseman,Robert C. Elston +1 more
TLDR
Procedures are given, using sib pairs, for estimating linkage between a knownm-allele locus and a hypothesized two-alleel locus that governs a quantitative trait.Abstract:
Procedures are given, using sib pairs, for estimating linkage between a knownm-allele locus and a hypothesized two-allele locus that governs a quantitative trait. Random mating and linkage equilibrium are assumed. Also given are parametric and nonparametric methods for detecting linkage when the trait in question is governed by several two-allele loci, provided there is no epistasis.read more
Citations
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Journal ArticleDOI
Common SNPs explain a large proportion of the heritability for human height
Jian Yang,Beben Benyamin,Brian P. McEvoy,Scott D. Gordon,Anjali K. Henders,Dale R. Nyholt,Pamela A. F. Madden,Andrew C. Heath,Nicholas G. Martin,Grant W. Montgomery,Michael E. Goddard,Peter M. Visscher +11 more
TL;DR: Evidence is provided that the remaining heritability is due to incomplete linkage disequilibrium between causal variants and genotyped SNPs, exacerbated by causal variants having lower minor allele frequency than the SNPs explored to date.
Journal ArticleDOI
Genetic dissection of complex traits
TL;DR: This article synthesizes the current state of the genetic dissection of complex traits--describing the methods, limitations, and recent applications to biological problems.
Journal ArticleDOI
Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees
Laura Almasy,John Blangero +1 more
TL;DR: It is shown how variance-component linkage methods can be used in pedigrees of arbitrary size and complexity, and a general framework for multipoint identity-by-descent (IBD) probability calculations is developed.
Journal ArticleDOI
Prediction of Bone-Density from Vitamin-D Receptor Alleles
Nigel Alexander Morrison,Jian Cheng Qi,Akifumi Tokita,Paul J. Kelly,Linda Crofts,Tuan V. Nguyen,Philip N. Sambrook,John A. Eisman +7 more
TL;DR: It is shown that common allelic variants in the gene encoding the vitamin D receptor can be used to predict differences in bone density, accounting for up to 75% of the total genetic effect on bone density in healthy individuals.
Genetic Dissection of Complex Traits
TL;DR: The current state of the genetic dissection of complex traits is summarized in this paper, which describes the methods, limitations, and recent applications to biological problems, including linkage analysis, allele-sharing methods, association studies, and polygenic analysis of experimental crosses.
References
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Book
Nonparametric statistics for the behavioral sciences
TL;DR: This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others as discussed by the authors, and the original structure is retained, and the book continues to serve as a combined text/reference.
Book
Rank correlation methods
TL;DR: The measurement of rank correlation was introduced in this paper, and rank correlation tied ranks tests of significance were applied to the problem of m ranking, and variate values were used to measure rank correlation.
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Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees
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