Journal ArticleDOI
The iodine concentration in benign and malignant thyroid nodules measured by X-ray fluorescence
TLDR
The detection of iodine in a thyroid nodule by X-ray fluorescence pre-operatively would significantly decrease the probability of malignancy and the need for surgical excision.Abstract:
Iodine concentration was measured by X-ray fluorescence in 48 normal thyroid glands obtained at autopsy and in 91 surgical thyroid specimens with a variety of abnormalities. The iodine concentration in normal thyroids ranged from 0.02 to 3.12 mg/g of tissue with a mean value of 1.03 ± 0.67 mg/g. The concentrations in pathological specimens were generally lower with the lowest values found in thyroid cancers. Sixteen (76%) of 21 malignant thyroid specimens analysed had undetectable iodine (< 0.02 mg/g) whereas 22 (96%) of 23 benign nodules had measurable iodine concentrations. The detection of iodine in a thyroid nodule by X-ray fluorescence pre-operatively would significantly decrease the probability of malignancy and the need for surgical excision.read more
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Toxicological profile for iodine
TL;DR: This edition supersedes any previously released draft or final profile and reflects a comprehensive and extensive evaluation, summary, and interpretation of available toxicologic and epidemiologic information on a substance.
Journal ArticleDOI
Trace elemental analysis of adenoma and carcinoma thyroid by PIXE method
S. Bhuloka Reddy,M. John Charles,M. Ravi Kumar,B. Seetharami Reddy,Ch Anjaneyulu,G. J. Naga Raju,B. Sundareswar,V. Vijayan +7 more
TL;DR: The concentrations of the elements Ca, Cu, Zn, As, I and Hg are found to be much lower in carcinoma thyroid than those in the normal thyroid while the concentration of K, Ti, V, Cr, Mn, Fe, Co and Sr in carcinomas thyroid are higher than the concentrations in normal thyroid.
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Normal human intrathyroidal iodine
V. Zaichiek,S. Zaichick +1 more
TL;DR: The range of intrathyroidal iodine parameters is wide enough to provide a possible explanation for the particular sensitivity of some population to both excessive and deficient iodine intake.
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Determination of normal human intrathyroidal iodine in Caracas population.
José Zabala,Nereida Carrión,Miguel Murillo,Mercedes Quintana,José Chirinos,Nelly Seijas,Leopoldo Duarte,Peter Brätter +7 more
TL;DR: The median intrathyroidal iodine concentration was 1443+/-677 microg/g (wet weight), which corresponds to a median of total iodine content of 15+/-8 mg, higher than those values reported in the literature.
References
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Journal ArticleDOI
Measurement of serum TSH and thyroid hormones in the management of treatment of thyroid carcinoma with radioiodine.
TL;DR: Serum levels of TSH, thyroxine and triiodothyronine have been measured during treatment and follow-up of patients with thyroid carcinoma and a tumour should not be considered as incapable of concentrating 131I adequately until serum TSH levels have exceeded 30 mU/l.
Journal Article
Differentiation between malignant and benign solitary thyroid nodules by fluorescent scanning.
TL;DR: In a preliminary study of 42 surgical patients, an iodine content ratio (ICR) below 0.60 (chosen a posteriori) proved to be an excellent indication of malignancy with a sensitivity of 100, a specificity of 79%, and an overall accuracy of 90%.
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Thyroid Iodine Content and Turnover in Euthyroid Subjects: Validity of Estimation of Thyroid Iodine Accumulation from Short-Term Clearance Studies
Delbert A. Fisher,T. H. Oddie +1 more
TL;DR: Measurements of thyroidal and renal radioiodine clearances, urinary iodine excretion and fractional thyroidalRadioiodine release rate were conducted in 18 euthyroid young adult subjects in presumed iodine equilibrium, enabling the thyroid iodine accumulation (A) to be calculated.
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Fluorescent excitation analysis: a simplified method of iodine determination in vitro.
TL;DR: Iodine concentrations in bile, serum, and urine were determined by fluorescent excitation analysis using Americium-241 as the excitation source and was accurate to ± 2% over an iodine concentration range of .2 to 50 mg/ml.