Book ChapterDOI
The Morphology of the Peritoneum in CAPD Patients
N. DiPaolo,G. Sacchi,U. Buoncristiani,P. Rossi,E. Gaggiotti,C. Alessandrini,L Ibba,Pucci Am +7 more
- pp 11-19
TLDR
The structure of the peritoneum has been studied by scanning and transmission electron microscopy and by light microscopy in 38 biopsies of 22 patients undergoing CAPD and after recovery the mesothelium is replaced by thick fibrous connective tissue.Abstract:
The structure of the peritoneum has been studied by scanning and transmission electron microscopy and by light microscopy in 38 biopsies of 22 patients undergoing CAPD. Before CAPD the mesothelium was characterized by flattened cells with protruding nuclei, numerous microvilli and many pinocytotic vesicles. After prolonged CAPD there is a reduction and subsequent disappearance of microvilli and a vacuolar separation of cells from the basement membrane, accompanied by widening of intercellular junctions. Neither ultrafiltration rate nor small solute clearance change with these structural alterations. During peritonitis there is extensive cellular necrosis with denuding of the basement membrane. After recovery the mesothelium is replaced by thick fibrous connective tissue.read more
Citations
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Journal ArticleDOI
Morphologic Changes in the Peritoneal Membrane of Patients with Renal Disease
John D. Williams,Kathrine Jane Craig,Nicholas Topley,Christopher John Von Ruhland,Maureen Fallon,Geoffrey R. Newman,Ruth K. Mackenzie,G. T. Williams +7 more
TL;DR: For the first time, a comprehensive cross-sectional analysis of the morphologic changes in the peritoneal membranes of patients undergoing PD is provided, suggesting that vasculopathy may predispose patients to the development of fibrosis.
Journal ArticleDOI
New Concepts in Molecular Biology and Ultrastructural Pathology of the Peritoneum: Their Significance for Peritoneal Dialysis
TL;DR: Evidence is accumulating that a process of nonenzymatic glycosylation of protein, similar to that which occurs in diabetes, is responsible for changes in stromal texture and the reduplication of basement membranes from the study of peritoneal biopsies in CAPD patients.
Journal ArticleDOI
Interleukin-8 production by human peritoneal mesothelial cells in response to tumor necrosis factor-alpha, interleukin-1, and medium conditioned by macrophages cocultured with Staphylococcus epidermidis.
Michiel G. H. Betjes,Cornelis W. Tuk,Dirk G. Struijk,Raymond T. Krediet,Lambertus Arisz,Margreet Hart,Robert H. J. Beelen +6 more
TL;DR: Human peritoneal mesothelial cells were shown to produce high levels of interleukin-8 (IL-8) in response to IL-1 beta and tumor necrosis factor-alpha (TNF alpha) but not lipopolysaccharide or S. epidermidis, which is important for the recruitment of granulocytes into theperitoneal cavity.
Journal ArticleDOI
Peritoneal vascular changes in continuous ambulatory peritoneal dialysis (CAPD): an in vivo model for the study of diabetic microangiopathy.
N Di Paolo,G. Sacchi +1 more
TL;DR: Replication of the basement membrane of the peritoneal capillaries and the mesothelium is observed in all uremic patients after a period of continuous ambulatory peritoneAL dialysis (CAPD).
Journal ArticleDOI
The source and possible significance of hyaluronan in the peritoneal cavity
TL;DR: The results indicate that the process of CAPD results in an increase in HA levels in the peritoneal cavity, which may be an initial event in wound repair during episodes of peritonitis.
References
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Journal ArticleDOI
Sclerotic Thickening of the Peritoneal Membrane in Maintenance Peritoneal Dialysis Patients
Vasant C. Gandhi,Hamid M. Humayun,T. S. Ing,J T Daugirdas,Victor R. Jablokow,Shunzaburo Iwatsuki,Geis Wp,Jessie E. Hano +7 more
TL;DR: Five patients receiving maintenance peritoneal dialysis required surgical exploration of the abdomen for various reasons, two of which had a prior history of bacterial peritonitis, and four of aseptic peritoneitis.
Journal Article
Regeneration of parietal and visceral peritoneum: an electron microscopical study.
TL;DR: An ultrastructure study was undertaken in an attempt to confirm the finding, obtained by light microscopy, that the new mesothelium arose by metaplasia of subperitoneal fibroblasts and not by transformation of peritoneal macrophages and to assess the role of detached mesothelial cells inPeritoneal regeneration.
Journal ArticleDOI
The ultrastructural morphology and possible functional significance of mesothelial microvilli.
Peter M. Andrews,Keith R. Porter +1 more
TL;DR: It is proposed that the serosal microvilli, together with their glycocalyx, harbor a layer of serious exudate and thereby create a slippery cushion designed to protect the thin mesothelium from frictional damage.
Journal ArticleDOI
Acute changes in peritoneal morphology and transport properties with infectious peritonitis and mechanical injury
TL;DR: The findings suggest that alterations of mesothelium might explain some of the changes in peritoneal transport properties under the conditions of these studies.
Journal ArticleDOI
Determinants of low clearances of small solutes during peritoneal dialysis
TL;DR: Typical values for clearances of urea and inulin, dialysis solution flow rate , blood flow rate, and surface area are compared for peritoneal and extracorporeal (hemodialysis) techniques.