Showing papers in "Kidney International in 1994"

TL;DR: An immortalized adult human PTC line has been established by transduction with HPV 16 E6/E7 genes and it appears to be well-differentiated on the basis of its histochemical, immune cytochemical, and functional characteristics, and it can reproduce experimental results obtained with freshly isolated PTCs.

TL;DR: A new approach is presented for routine monitoring of the body fluid variation in the single patient, without making any assumption on body composition, based on the analysis of the bivariate distribution of the impedance vector in a healthy population and in patients with increased body weight, due to either obesity or edema from renal diseases.

TL;DR: It is found that TGF-beta 1 expression and increased matrix production is transient and self-limited in nephritic glomeruli from rats with acute, reversible glomerulonephritis induced by a single injection of an antibody reactive with glomerular mesangial cells.

TL;DR: The data have now been confirmed and support the view that ANCA-associated glomerulonephritis and vasculitis is, indeed, a distinct disease category, and a critical reappraisal of the diagnostic significance of AN CA-testing seems justified.

TL;DR: Outcome predictions based on the strongest clinical model (serum creatinine, hematocrit and race) were significantly enhanced by the addition of renal pathology data, and consideration of these prognostic factors may contribute to decisions regarding the type and intensity of immunosuppressive therapy for patients with lupus nephritis.

TL;DR: The presence of naturally occurring inhibitors of interleukin-1 (IL-1) and tumor necrosis factor (TNF) in a variety of diseases has been demonstrated as discussed by the authors.

TL;DR: The increased risk of RCN among diabetics was associated with exaggerated renovascular reactivity: baseline vasoconstriction and enhanced vasodilation with vasodilator/diuretic drugs.

TL;DR: The results show that pre-HD plasma AA profiles were abnormal compared to controls and decreased significantly during HD with all dialyzers, and the use of HF-PS membranes resulted in significantly more AA losses into the dialysate when compared to LF-PMMA membranes.

TL;DR: Monitoring of nitric oxide release from endothelial cells using a highly-sensitive amperometric NO-sensor indicates that the observed IGF-I-induced release of NO is a result of activation of the constitutive, rather than the inducible type of NO synthase in endothelium cells.

TL;DR: The effects of specific intervention in the renin-angiotensin system with the Ang II receptor antagonist losartan and enalapril were investigated and compared these effects to those obtained with ACE inhibition, as this comparison might resolve the question whether or not the effects of ACE inhibition are Ang II related.

TL;DR: A randomized, controlled multicenter investigation of Icodextrin in ambulatory peritoneal dialysis (MIDAS) was undertaken to evaluate the long-term safety and efficacy by comparing daily overnight use of isosmolar I codextrin with conventional 1.36% and 3.86% glucose exchanges over six months.

TL;DR: It is demonstrated that adynamic bone disease does not merely represent an academic finding but is characterized by a very low bone capacity to buffer calcium and inability to handle an extra calcium load, particularly relevant for the daily care of end-stage renal failure patients presently receiving higher than ever amounts of vitamin D and calcium salts.

TL;DR: Adynamic renal osteodystrophy develops in a substantial number of patients during intermittent calcitriol therapy, although declining serum PTH and alkaline phosphatase levels suggest the development of the adynamic lesion, bone formation decreases in some patients despite persistently high serum P TH levels.

TL;DR: Kidney stone prevalence increased with age until age 70, then declined and was higher in men than women and in whites than blacks, and among Hispanic and Asian men was intermediate between that of whites and blacks.

TL;DR: Investigation of uremic patients who often develop accelerated atherogenesis revealed that peritoneal dialysis treatment ameliorated the oxidation markers, however, a prolonged dialytic treatment caused a decrease in vitamin E concentration in LDL and increased their susceptibility to oxidation.

TL;DR: During the normal transit time of urine through the nephron, crystalline particles can be formed which are large enough to be retained because of their size and thus form the nidus of a stone.

TL;DR: It is proposed that collapsing glomerulopathy is a distinct entity characterized by black racial predominance, massive proteinuria, relatively rapidly progressive renal insufficiency, and distinctive pathologic findings.

TL;DR: On morphological and clinical grounds, CHN appears similar to BEN; a common etiologic agent, aristolochic acid, is suspected and the known carcinogenic potential of this compound is taken together with the finding of multiple foci of cellular atypia of the urothelium suggest that CHN patients should undergo a regular follow-up for Urothelial malignancy.

TL;DR: In this article, the most effective route (intravenous vs. "pulse" oral), dose (physiologic vs. pharmacologic) and long-term efficacy of calcitriol therapy for secondary hyperparathyroidism in patients with end-stage renal disease (ESRD) was examined.

TL;DR: It is concluded that two iNOS isoforms are constitutively and heterogeneously expressed in the normal rat kidney, and that endotoxemia and cytokines differentially induce their expression.

TL;DR: The primary results of a three-year prospective, double-blind, placebo-controlled trial in non-insulin-dependent diabetic (NIDDM) patients show that an anti-hypertensive regimen, which includes the ACE inhibitor enalapril, preserves renal function to a greater extent than therapy with antihypertension agents excluding ACE inhibitors.

TL;DR: Total RNA was extracted from renal cortex and isolated glomeruli of streptozotocin-induced diabetic rats 24 hours, 48 hours, 96 hours, one and two weeks after the onset of hyperglycemia.

TL;DR: Recent advances in immunopathology research have identified leukocyte adhesion as a pivotal event in inflammation that may be amenable to therapeutic intervention, which may antecede the development of potent and specific new agents for the treatment of inflammatory diseases of the kidney.

TL;DR: Coincident extensive tubular atrophy was associated with interstitial fibrosis and a nonspecific mononuclear cell infiltrate; there was no evidence of vasculitis.

TL;DR: The effect of theophylline (TP), an adenosine receptor antagonist, regarding changes in renal hemodynamics induced by CM is investigated in a double-blind, placebo-controlled study.

TL;DR: Analysis of angiotensin II infusion in the rat kidney suggests that osteopontin over-expression may facilitate monocyte/macrophage accumulation at the sites of renal tubulointerstitial injury.

TL;DR: Part 1 Lipids as a risk factor for renal disease: lipid abnormalities in progressive renal insufficiency hypertension, hyperlipidemia and microalbuminuria apolipoprotein E phenotype and renal disease lipoprotein glomerulopathy role of lipids in chronic renal allograft rejection.

TL;DR: Mortality analyses adjusted for pre-treatment risk factors suggest that CAPD and HD provide incident non-diabetic ESRD patients with similar expected survival outcomes and suggests the need for further controlled studies of mortality among CAPD Patients with diabetes.