Journal ArticleDOI
The nature of the suppressive effect of interferon and interferon inducers on the in vitro immune response.
Howard M. Johnson,Samuel Baron +1 more
TLDR
It was shown that at least two antigenically distinct interferons may be involved in suppressing the immune response, and interferon was effective in inhibiting the in vitro PFC response of antigen-primed spleen cells, indicating that it can block the response of memory lymphocytes.About:
This article is published in Cellular Immunology.The article was published on 1976-07-01. It has received 76 citations till now. The article focuses on the topics: Interferon inducer & IRF1.read more
Citations
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Journal ArticleDOI
Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis.
G Trinchieri,D Santoli +1 more
TL;DR: Cell separation experiments support the hypothesis that interferon enhances the activity of natural killer cells rather than generating a new population of effector cells, and might render the natural killer cell system an inducible selective defense mechanism against tumor and virus-infected cells.
Journal ArticleDOI
At least three human type alpha interferons: structure of alpha 2
TL;DR: The sequence of a human leukocyte-derived complementary DNA, Hif-2h, which directs the formation in Escherichia coli of a polypeptide, IFN-alpha 1, with interferon (IFN) activity has been described, revealing the presence of at least eightIFN-related genes.
Book ChapterDOI
Interferons with special emphasis on the immune system
TL;DR: First described in 1957, interferon are induced animal proteins that inhibit a wide range of viruses by inducing an intracellular antiviral state; however, many interferons are species-specific in their antiviral activity.
Journal ArticleDOI
Interferon: Immunobiology and Clinical Significance
TL;DR: Interferon has not been proved to help children with congenital cytomegalovirus or rubella, but it can shrink lymphoid tumors, particularly non-Hodgkin's lymphoma.
Journal ArticleDOI
Mechanisms of activation of human natural killer cells against tumor and virus-infected cells.
Daniela Santoli,Hilary Koprowski +1 more
TL;DR: A number of investigators have recently described specific cytotoxic effects of human lymphocytes against human target cells, but these studies have been hampered by the fact that lymphocytes from normal donors were at least as reactive as those from cancer patients.
References
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Journal ArticleDOI
Immunization of dissociated spleen cell cultures from normal mice
TL;DR: There is an increase in the ability to discriminate between different varieties of homologous erythrocytes and the in vitro response does not appear to be limited by whatever mechanisms regulate the in vivo response.
Journal ArticleDOI
Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. I. Characterization of the inhibitory cell activity.
TL;DR: The presence of concanavalin A inhibits the immune response of mouse spleen cell suspensions to erythrocyte antigens, stimulates the incorporation of tritiated thymidine, and increases cell recovery, compatible with the hypothesis that there are at least two cell targets for the action of Con A.
Journal Article
A Modification of the Hemolytic Plaque Assay for Use with Protein Antigens
TL;DR: The method is simple and sensitive and the results mimic the kinetics of the response that is seen in in vivo assays of serum antibody.
Journal Article
Effects of Interferon on Antibody Synthesis in Vitro
TL;DR: It was found that in “low-responder” composite cultures, pretreatment of the B cell population with low amounts of interferon led to a considerable enhancement of the antibody response, whereas higher concentrations of Interferon gave a similar degree of inhibition as that found for “high-responding” cultures.
Journal Article
Regulation of the Immune System by Synthetic Polynucleotides I. Characteristics of Adjuvant Action on Antibody Synthesis
TL;DR: Poly(A:U) increased the antibody response to a variety of antigens including both soluble and particulate proteins, sheep red blood cells, and a polysaccharide, the Vi antigen of Escherichia coli and was capable of rendering 1 ng of bovine γ globulin immunogenic.
Related Papers (5)
Effects of Interferon on Antibody Synthesis in Vitro
Production and properties of migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity.
J. S. Youngner,S. B. Salvin +1 more